Since lymphoid tissue inducer (LTi) cells, the key hematopoietic cell type responsible for lymph node formation, constitutively express high levels of both OX40L and CD30L in the adult, but not the embryo (when lymph nodes form), we investigated whether these cells were involved in memory ...
Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells, comprise the first line of innate immune defense against pathogens and tumors. Over the past decade, accumulating evidence has demonstrated immunological memory in ...
ILCs include lineage marker negative (lin-) ILCs,natural killer (NK) cells, and lymphoid tissue-inducer (LTi) cells. Three distinct groups of ILCs have been classified based upon their immune response of Type 1, 2, and 3. Grou...
cells, PD-1 is also substantially expressed in colonic lymphoid tissue inducer (LTi) cells. During DSS-induced colitis, LTi cell activation is accompanied by increased PD-1 expression, whereas PD-1 deficiency results in reduced interleukin-22 (IL-22) production by LTi cells and exacerbated ...
Lymphoid tissue is a ‘three-dimensional meshwork’ consisting of reticular fibers and fixed cells (macrophages and reticular cells) within which are lymphocytes, plasma cells, and granulocytes (Rose, 1981). From: Handbook of Vertebrate Immunology, 1998 ...
Lymphoid tissue inducer cells: innate cells critical for CD4+ T cell memory responses? Lane PJ;Gaspal FM;Mc Connell FM;.Lymphoid tissue inducer cells:innate cells critical for CD4+T cell memory responses?.Ann New York Aca Sciences.2012.1... PJL Lane,FM Gaspal,FM Mcconnell,... - 《Annals...
IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46. Nat. Immunol. 11: 1030– 1038. Google Scholar Crossref PubMed WorldCat 70. Qi, J., A. Crinier, B. Escalière, Y. Ye, Z. Wang, T. Zhang, L. Batista, ...
Here, we argue that lymphoid tissue inducer cells played a pivotal role not only in the development of organized lymphoid structures but also in the subsequent genesis of the CD4-dependent class-switched memory antibody responses that depend on an organized infrastructure to work. In this review, ...
(NK) cells and lymphoid tissue inducer (LTi) cells, which were first discovered in 1975 and 1997, respectively (Kiessling et al.,1975a; Kiessling et al.,1975b; Mebius et al.,1997), and other recently described subsets. ILCs can be generally identified by their expression of certain ...
Innate lymphoid cells are an emerging family of effector cells that contribute to lymphoid organogenesis, metabolism, tissue remodelling and protection against infections. They maintain homeostatic immunity at barrier surfaces such as lung, skin and gut (Nature 464:1367–1371, 2010, Nat Rev Immunol 13...