cells (ILC3s) protect the intestinal epithelium from TNF-induced cell death. This occurs independent of interleukin-22 (IL-22), and we identify that ILC3s are a dominant source of heparin-binding epidermal growth factor–like growth factor (HB-EGF). ILC3s produce HB-EGF in response to ...
sheathand is composed of T- and B-cell areas and follicles containinggerminal centers. Dendritic reticular cells and phagocytic macrophages found in germinal centers present antigen to lymphocytes. The germinal centers are where B cells are stimulated to become plasma cells that produce and secrete ...
The spleen colony-forming stem cell (CFU-S)(Till and McCulloch 1961) produces myeloid and erythroid progeny but lacks the ability to produce lymphocytes (Paige et al 1979). The existence of a similar lymphoid-restricted stem cell remains controversial. In studies on the reconstitution of ...
The spleen colony-forming stem cell (CFU-S)(Till and McCulloch 1961) produces myeloid and erythroid progeny but lacks the ability to produce lymphocytes (Paige et al 1979). The existence of a similar lymphoid-restricted stem cell remains controversial. In studies on the reconstitution of ...
Although ILCs lack the the cell receptor (TCR), these cells have a similar functional diversity in terms of lineage-specifying transcription factors, such as T-bet, GATA-3 and RORγt and with respect to effector functions1,2. Group 2 ILCs (ILC2s) depend on GATA-3 and produce type 2 ...
cellsor noncytolytic INF-γ–producing ILC1 cells. ILC2 cells populate somemucosal tissueslike the fetal intestine during development.460They also populate the lung. These cells express receptors for IL-33 and IL-7 and can produce IL-5 and IL-13. As IL-13 is a major driver of mucin ...
The group 1 ILC lineage comprises ILCs such as natural killer (NK) cells that produce type 1 cytokines, notably interferon-γ and tumour necrosis factor. Other group 1 ILCs have been reported, mainly in vitro, and their physiological roles remain to be defined. The group 2 ILC population com...
Continuous coculture results in two distinct populations, B220 c-Kit cells and B220 c-Kit cells; B220 c-Kit cells are self-renewed and differentiate to B220 c-Kit cells, while B220 c-Kit cells produce only B220 c-Kit cells. Both B220 and...
transcription factor RoRyt and produce Th17- and Th22-like cytokines, are required for host defense against extracellular bacteria and fungi. Though all ILCs are derived from HSCs but little is known about the role of ILCs in stem cell therapy and regulation of ILCs by stem cells during ...
Typically, CTLA-4 expressing Foxp3+ CD4+ TREG cells produce the anti-inflammatory cytokine IL-1066. Therefore, we sought evidence for a population of CD127+ ILC co-expressing IL-10 and CTLA-4 in the cLP and small intestine lamina propria of BALB/c mice. We detected no IL-10-producing ...