Several independent groups have developed methods aimed at identifying antigens that are expressed on human tumors and can be recognized by T lymphocytes. The positively identified antigens can be presently classified as follows: 1) antigens derived from genes whose functions are still unknown that ...
Tumor-infiltrating lymphocytes in Breast Cancer and implications for clinical practice Breast Cancer (BC) can be classified using pathologic features, such as grade and tumor size. It can be categorized based on the gene expression profile, w... Deborade,Melo,Gagliato,... - 《Biochimica Et Bio...
Breast Cancer (BC) can be classified using pathologic features, such as grade and tumor size. It can be categorized based on the gene expression profile, which identifies the distinct molecular subtype. More recently, stromal tissue has been recognized as an important modulator of tumor cell growt...
A more primitive and alternative mechanism exists whereby NK-cells, classified as large granular lymphocytes (LGL), are able to kill in a non-specific manner, not requiring prior sensitisation to antigen. Both antigen-specific T-cells and LGL mediate their cytotoxicity through the release of ...
colitis may actually be classified as a Th17 disease, while Crohn’s disease remains a Th1 disease. Similar results were reported for peripheral blood cells (Raza and Shata2012; Veny et al.2010). Although, other researchers confirmed activation of Th17 pathway in intestinal mucosa and mesenteric ...
NR to NAT was defined as cases without obvious chemotherapy response in the primary tumor (Miller–Payne Grade 1: No change or some alternation to individual malignant cells but no reduction in overall cellularity10) or in metastatic lymph nodes (Classified as grade N–C according to the Sata...
Immune checkpoint blockade has revolutionized cancer treatment1. Colorectal cancer (CRC) can be classified into microsatellite instable (MSI) and microsatellite stable (MSS) cancers that differ in their clinical course and response to treatment. Only MSI CRC benefit from targeting the PD-1/PDL1 or ...
OCT is currently used for detailed assessment of IMHs and regarded as the diagnostic gold standard [25]. This study included 36 patients with IMH (IMH group) and 36 sex-and-age-matched patients with cataracts (control group). According to Gass staging, the IMH group was classified using OCT...
For example, if the frequency of INF-γ-producing cells from an individual corresponds to a reference frequency of INF-γ-producing cells derived from a population of unstable angina patients, then that individual can be classified as being predisposed to have an unstable angina condition. Again,...
Triple-negative breast cancer represents the worst type of breast cancer and can be classified into four different subtypes: basal-like (BL), mesenchymal (M), luminal androgen receptor (LAR), and immunomodulatory (IM). Some triple-negative breast cancers have high levels of immune cell ...