Similarly, also FOSB is recognized as a marker of Active NK cells. Belonging to the very early activator protein (AP)-1 transcription factor family, its upregulation is correlated to natural cytotoxicity exerted by the human NK lymphocytes upon stimulation [38]. Notably, CD69 and FOSB are the...
Because autologous tumors are generally unavailable, an allogeneic choroidal melanoma cell line, OCM-1, was used as the specific stimulus. Lymphocyte cultures from 27 patients were characterized by cell-surface phenotypes, patterns of reactivity towards cells of the melanocytic origin and T-cell-...
Figure 3 shows that the level of translocation frequencies in A-bomb survivors generally agreed with the in vitro dicentric frequencies measured with conventional staining method up to 2.5 Sv. However, as the dose increases, the translocation frequencies fall off around 3 Sv. Such a leveling off ...
The expected nuclear staining pattern was optimized on benign lymph node tissue, which was also used as the positive control for each batch and to assess technical consistency of staining between batches. Images of the FOXP3-stained TMA cores are available at our TMA image website [34]. FOXP...
also FOSB is recognized as a marker of Active NK cells. Belonging to the very early activator protein (AP)-1 transcription factor family, its upregulation is correlated to natural cytotoxicity exerted by the human NK lymphocytes upon stimulation [38]. Notably, CD69 and FOSB are the most signi...
Conclusions FOXP3+ regulatory TILs are a poor prognostic indicator in ER+ breast cancer, but a favorable prognostic factor in the HER2+/ER+ subtype. The prognostic value of FOXP3+ TILs in breast cancer differs depending on ER and HER2 expression status and CD8+ T-cell infiltration.Similar...
With limited studies dedicated towards sarcomas in general, and in particular across the various subtypes, and considering their generally poor prognosis, more robust and effective treatments are urgently needed—in this regard, immunotherapy strategies offer potential value [14]. In the past decade, ...
Ulcerative colitis (UC) is generally regarded as a chronic, inflammatory, idiopathic condition. Although the primary effects are seen in the gastrointestinal tract, it can likewise present with important extraintestinal manifestations, at the skin, joint, liver, and eye level. UC manifests itself in...
Interestingly, while low ITB generally correlated with a good prognosis, we found this group to be heterogeneous as well. Therefore, ITB and IS alone may not be sufficient for comprehensive prognosis stratification in CRC. ITB is one aspect of tumor progression that can be seen, and it is ...
This effect, in cases only, was less than additive but still a significant increase in HCMV + radiation induced MN as compared to radiation (7.14 vs. 11.73) and virus (10.52 vs. 11.73) alone. There are a number of plausible explanations to such an observation: first, HCMV infection may...