such as thelymph nodes,spleen, andtonsils(Figure 3), where they await activation through the presentation of specific antigens by APCs. Until they are activated, they are known asmature naïve T cells. Figure
each group was stratified into two subsets based on protective antibody levels. Patients with antibody levels ≥ 1:160 were categorized as “responders” (R), while those with lower levels were categorized as “non-responders” (NR). Unsupervised clustering of pseudo...
Figure 3 shows that the level of translocation frequencies in A-bomb survivors generally agreed with the in vitro dicentric frequencies measured with conventional staining method up to 2.5 Sv. However, as the dose increases, the translocation frequencies fall off around 3 Sv. Such a leveling off ...
In particular, observed tenfold increase of the proportion of CD4+CD282 lymphocytes in high responders should rather lead to an increase in IFNc production, as these cells are known to manufacture significant amounts of this cytokine (e.g. [42,43] ). Thus, we hypothesi...
Due to the low number of cells in this cluster, metacluster 6 could also be the result of overclustering, which is generally recommended to capture small relevant cell clusters31. Nevertheless metacluster 6 frequency did not differ between the two groups. CD21−CD27− B cells are ...
The expected nuclear staining pattern was optimized on benign lymph node tissue, which was also used as the positive control for each batch and to assess technical consistency of staining between batches. Images of the FOXP3-stained TMA cores are available at our TMA image website [34]. FOXP...
Several studies have shown that the proportions of circulating B-cells in SCA are generally unaltered [27, 41, 42]. Venkataraman and Westerman [43] showed no significant changes in the percentage of B-cells in SCA patients at steady state compared to control group individuals; however, they sh...
Interestingly, while low ITB generally correlated with a good prognosis, we found this group to be heterogeneous as well. Therefore, ITB and IS alone may not be sufficient for comprehensive prognosis stratification in CRC. ITB is one aspect of tumor progression that can be seen, and it is ...
This effect, in cases only, was less than additive but still a significant increase in HCMV + radiation induced MN as compared to radiation (7.14 vs. 11.73) and virus (10.52 vs. 11.73) alone. There are a number of plausible explanations to such an observation: first, HCMV infection may...