确实,Ly6C的缺失嗨单核细胞与严重的病毒诱导的免疫病理和促炎介质的全身释放有关。” 在机制上,病毒印迹单核细胞将CD4 T细胞招募到气道,其中一些是调节性T细胞。同时,这些单核细胞通过PD-L1/PD-1轴启动免疫抑制信号通路,减弱细胞毒性CD4 T细胞的有害激活。”席琳Maquet解释道。这些结果突出了Ly6C的作用嗨单
确实,Ly6C的缺失嗨单核细胞与严重的病毒诱导的免疫病理和促炎介质的全身释放有关。” 在机制上,病毒印迹单核细胞将CD4 T细胞招募到气道,其中一些是调节性T细胞。同时,这些单核细胞通过PD-L1/PD-1轴启动免疫抑制信号通路,减弱细胞毒性CD4 T细胞的有害激活。”席琳Maquet解释道。这些结果突出了Ly6C的作用嗨单核细胞在...
2011. Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection . Immunity 35 :633–646. 10.1016/j.immuni.2011.08.016 [ Cross Ref ]Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, et al. Differential ...
CCR2 antagonist reduced percentages of IFNγ+ IL10+ double producer CD4 cells. Splenocytes were harvested fromL. donovaniinfected, CCR2A, CCR2B and vehicle treated mice at 30 dpi, re-stimulated with LdAg for 72 h, and release of cytokines was evaluated in the culture supernatants. (A...
淋巴细胞亚群结果显示,CD8+T细胞占比有所降低(图1B),CD4+T细胞和CD19+B细胞百分比并无显著改变(图1C和1D)。值得注意的是, CD11b + CD14 +单核/巨噬细胞的数量在脑损伤立即增加(图1E左)。荧光流式分选结果显示TBI患者血液...
它们由异质细胞群组成,具有表面标记物ESAM、MGL2 (CD301b)、DCIR2或Clec12a和转录因子T-bet或RORγt的差异表达这些标记物和转录因子常用于将DC2s细分为不同的亚群,ESAM+DC2s和ESAM DC2s19或T-bet+DC2A和RORγt+DC2B这些DC2亚群...
Differential labeling of CXCR1-GFP cells in the blood and the tissue showed CD4 T cell dependent accumulation of PD-L2 CXCR1-GFP AAM in the tissues as granulomas form. By adoptive transfer of Ly6C(high) and Ly6C(low) monocytes into infected mice, we found that AAM originate primarily from...
Administration of PD-L2+ AAMφs significantly blunted the presence of IL-17 and IFN-γ producing CD4+/CD44+ cells, and CD25+/Foxp3+ regulatory T (Treg) cells (Fig. 5f), whereas T-bet+ and IFN-γ producing T-bet+ cells were also reduced in the CNS (Fig. 5f). We...
We chose anti-CD4, anti-CD8a, anti-CD45R/B220, anti-Ly6G, and anti−TER-119 antibodies to delete T cells, B cells, neutrophils, and erythroblasts, while anti−c-kit, anti−Sca-1, anti−Thy-1.2, and anti−IL-7R α-chain antibodies were used to delete hematopoietic stem/...
1d). HFHCD and 60% HFD consumption led to comparable elevated production of TNFα by CD4+ T cells and IFNγ by CD8+ T cells and decreased levels of regulatory T cells, without change in other T cell populations (Fig. 1e). These data show that the consumption of a HFHCD for 2 ...