Alternatively, a panel of autoantibodies, possibly combined with cytokines and gene expression levels, might be useful. The skewed demographics of SLE can also be exploited, including the higher prevalence in females, first- degree relatives and individuals < 40 years old, permitting focus on those...
Responses to vaccination and to diseases vary widely across individuals, which may be partly due to baseline immune variations. Identifying such baseline predictors of immune responses and their biological basis is of broad interest, given their potentia
FIGS.1A-E show serum biomarker panel discriminating Active SLE vs. Normal. FIG.1A shows backward elimination analysis of the training set, resulting in a condensed set of 25 antibodies (marked with an arrow) providing the best classification. FIG.1B shows AUC ROC curve for the test set, bas...