Lupus nephritis class II is one of the features used in our algorithm. However, our regex did not include this specific variation of wording for lupus nephritis class II. This pattern could be incorporated in the NLP in the future to improve algorithm performance. In another example, a 26-...
we used ICD codes to extract disease status (Supplementary Table3). For ANA test result, we considered a titer of ≥1:80 (e.g., 1:80, 1:160, 1:320, etc.) as positive, and the other values as negative (e.g., negative status, 1:40, 1:20, and etc.). For anti-dsDNA test ...
We identified patients aged 18 to 65 years with prevalent SLE (≥3 visits ≥30 days apart with ICD-9 codes of 710.0) and prevalent LN (≥ICD-9 codes for nephritis, proteinuria and/or renal failure on or after SLE diagnosis, ≥30 days apart). We defined serious bacterial, viral, fungal...
Lupus nephritis, as indicated by SLICC to be indicative of a positive SLE diagnosis in the presence of positive ANA, was the 25th most important CUI according to Table 5, showing that CUIs are capturing data pertinent to the classification of SLE [15]. Additionally, the table revealed ...
In B6.Nba2 congenic lupus mice, Tlr9 deletion led to accelerated lupus with an increased production of anti-nuclear antibodies and augmented lupus nephritis, while disease progression in the Tlr7/9 double-deficient mice was restored to a comparable or even slightly improved level as the parental ...
3-NOD, LRR and pyrin domain-containing protein 3; MDSC-Myeloid-derived suppressor cells; PBMC-peripheral blood mononuclear cell; JNK-c-Jun N-terminal kinase; LPS-lipopolysaccharide; ROS-reactive oxygen species; BUN-Blood Urea Nitrogen; TCE- trichloroethene; ASLN-accelerated severe lupus nephritis;...