Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis 原文链接:https://doi.org/10.1073/pnas.2116271119 Significance 目前基于mRNA技术的应用主要局限于肝脏疾病,因为缺乏特异性和高效的肝外的体内mRNA递送系统。在这里,我们开发了一个n系列脂质纳米颗粒...
Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis. Proc Natl Acad Sci U S A. 2022; 119. Hajiaghapour Asr M, Dayani F, Saedi Segherloo F, Kamedi A, Neill AO, MacLoughlin R, Doroudian M. Lipid nanoparticles as Promising ...
To summarize the mechanisms and pathophysiological features of ALI after burn. To classify the targets for the treatment of ALI. Describe the types of nanomedicines used to treat ALI. These findings suggest the prospects and outlook for nanomaterial-targ
Use of siRNA-based approaches, however, have certain limitations that prevent their maximal exploitation as cancer therapies. To address this, in the conclusion of this review, we provide a list of nanomedicine-based HuR targeting approaches currently being employed for siRNA and shRNA delivery, ...
Because RNA-RNA and RNA-DNA duplexes are highly selective, scientists have explored therapeutic potential of oligonucleotide-based molecules. Nucleic-acid-based therapeutics are currently used in two ways. RNA interference (RNAi) uses double-stranded RNAs, whereas ASOs are single-stranded RNAs. Small...
bacterial or human sources that function by mimicking the natural ligand 2’ 3’-cGAMP of STING, such as c-di-GMP and c-di-AMP et al. [63]. Additionally, clinical trials are currently underway for some synthetic CDN and non-CDN STING agonists, such as ADU-S100, MK-1454, and others ...
(DOPE), and cholesterol, and two synthetic lipids derived from cholesterol, ADP-2k and ADC, which are newly developed for mRNA delivery47(Fig.2b). The PEGylated lipid, ADP-2k, proved to be key to the successful encapsulation of RNPs into LNPs and delivery to NPCs (Extended Data Fig.3)....
A drug conjugate consists of a cytotoxic drug bound via a linker to a targeted ligand, allowing the targeted delivery of the drug to one or more tumor sites. This approach simultaneously reduces drug toxicity and increases efficacy, with a powerful combi
Rexinoids are ligands which activate retinoid X receptors (RXRs), regulating transcription of genes involved in cancer-relevant processes. Rexinoids have anti-neoplastic activity in multiple preclinical studies. Bexarotene, used to treat cutaneous T cell
Due to their non-immunogenicity, exceptional biocompatibility, and loading capacity, LNPs have become the most successful mRNA delivery vehicle entering the clinic. Amidst COVID-19 pandemic, two mRNA vaccines, the BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna), have been granted Emergency Use...