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In breast cancer, prolactin-induced activation of the transcription factor STAT5a results from the phosphorylation of STAT5a tyrosine residue 694. However, its role in mammary oncogenesis remains an unsettled debate as STAT5a exhibits functional dichotom
After 4 hours, blood samples were collected and prepared for serum. FITC-d levels of diluted sera were measured at an excitation wavelength of 485 nm and an emission wavelength of 528 nm (FilterMax F5 Multi-Mode microplate reader; Molecular Devices, San Jose, CA) and calculated from a ...
Classification of clinical phenotypes by age at onset of neurological symptoms (except for the cholestatic rapidly fatal form) (Vanier and Suzuki 1996). DNA and RNA Isolation Genomic DNA was isolated from skin fibroblasts or from whole blood, according to the protocol of Jeanpierre et al. (1987...
SCUBE2 expression in both tumors and blood is significantly associated with bone metastasis risk, suggesting its prognostic value in luminal cancer. More importantly, our study provides the rationale to target SCUBE2 and its downstream Hedgehog signaling for metastasis treatment. Hedgehog signaling in tu...
[56]. Kim et al. performed a 49-gene signature specific for the analysis of tumor-cell dormancy (gene profiles including tumor cell quiescence and angiogenic regulation) in both BC cell lines and primary BC tumors, with the aim of finding the correlation between the dormancy gene profile and...
S6C). Functional terms and pathways specifically overrepresented for GE and ST were related to NABA core matrisome, hexose metabolic process, apoptosis, activation of blood cells, and immune response signaling (Fig. S6). Upstream regulator analysis for each cell type Potential upstream regulators of...
To further corroborate this finding, we analysed a large gene expression data set for breast cancers with treatment and prognostic information (the Metabric data set)18 (Fig. 1f). Among the 220 ER þ breast cancer patients with no adjuvant treatment, those with TLK2-high tumours showed ...
20040024329Method and device for determining the segmental volume and electrical parallel conductance of a cardiac chamber or blood vessel2004-02-05Jansen et al. 6666828Catheter system having disposable balloon2003-12-23Greco et al. 6663661Endovascular support device and method2003-12-16Boneau ...
Formulations suitable for parenteral administration include aqueous and non-aqueous sterile injection solutions which may contain anti-oxidants, buffers, bacteriostats and solutes which render the formulation isotonic with the blood of the intended recipient; and aqueous and non-aqueous sterile suspensions ...