Here, we use a 3D model of the dendritic spine to investigate how polymerization of actin filaments can effectively elevate the membrane tension to trigger exocytosis in a domain close to the tip of the spine. Moreover, we show that the same pool of actin promotes full membrane fusion after...
Full size image Thrombin and PAR1 inhibition restore tetanus induced LTP in OGD exposed hippocampal slices Since iLTP is considered to be a pathological form of synaptic plasticity, which alters the plastic properties of healthy neuronal networks4, we reasoned that physiological, i.e., tetanus-indu...
consumingworkforresearcherstodevelopafull NLPplatform,especiallyforChinese,whichhas fewerexistingNLPtools.Therefore,itshouldbe ofparticularconcerntobuildanintegratedChi- neseprocessingplatform.Therearesomekey problemsforsuchaplatform:providinghighper- formancelanguageprocessingmodules,integrat- ingthesemodulessmoothly,...
Download: Download full-size image Figure 1. Diagram of the Recording Setup A mouse is attached to a recording cable and placed inside a 49 cm diameter, 34 cm high cylinder. The other end of the cable goes to a 25-channel commutator whose fixed side is attached to a computer-based spike...
Download: Download full-size image Figure 1. Ca2+-Stimulated Adenylyl Cyclase Activity Is Ablated in Brains of DKO Mice (A and B) Membrane preparations from the hippocampus (A) or cerebellum (B) of wild-type (WT, closed circles; n = 9), AC1 (ACI-M, open triangles; n = 5), AC8...