Download: Download full-size image Figure 4. The Protein Phosphatase 1 and 2A Inhibitor CA Selectively Enhances the Induction of LTP by Long Trains of 5 Hz Stimulation (A) In vehicle control experiments (0.2% DMSO, open symbols), LTP was not induced by 1 min of 5 Hz stimulation (fEPSPs...
Present address: 9Current address: College of Medicine Office of Research, University of South Florida, Tampa, FL 33612, USA, Jennifer E Ayala and Yelin Chen: These authors contributed equally Authors and Affiliations Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, ...
For ERK1/2 phosphorylation assay, the cells were then trypsinized and replated into poly-D-lysine-precoated 12-well plates at a density of about 6 Â 106 cells per well in full DMEM with 10% FBS. The second day, the medium was switched to full DMEM with G-5 supplement (Invitrogen...
These results indicate that only c-Fos-positive LA cells activated during cued FC undergo a potentiation in AMPAR-mediated synaptic transmission consistent with previous observations.13,35 Download: Download high-res image (2MB) Download: Download full-size image Figure 4. Subthreshold FC induces c-...
These results indicate that although mTOR signaling may be enhanced homeostatically in the FKBP12 cKO mice, its downstream targets are differentially regulated. Download: Download high-res image (326KB) Download: Download full-size image Figure 2. mTOR Phosphorylation, S6K Phosphorylation, and mTOR-...
Ginkgo biloba extract 761 (EGb761), a standardized extract from the Ginkgo biloba leaf, is purported to inhibit NMDA receptor-mediated neuronal excitotoxicity and protect neurons form ischemic injury. However, the specific signal pathway involved in the effects of EGb761 on synaptic plasticity is ...