Histone demethylase LSD1 plays key roles during carcinogenesis, targeting LSD1 is becoming an emerging option for the treatment of cancers. Numerous LSD1 inhibitors have been reported to date, some of them such as TCP, ORY-1001, GSK-2879552, IMG-7289, IN
60], was identified as an irreversible and weak LSD1 inhibitor [51,61]. Currently, 26 studies have been registered inclinicaltrials.govwebsite under the term “tranylcypromine,” three of them are undergoing for evaluating the therapeutic
aClinicalTrials.gov trial registry number. effects of LSD on functional magnetic resonance imaging (fMRI) study outcomes across subjects with prior LSD use (Speth et al, 2016; Tagliazucchi et al, 2016). Music has typically been used in substance-assisted psychotherapy (Gasser et al, 2014, ...
We modelled data from two randomised, placebo-controlled, double-blind, cross-over trials, in which 45 participants were administered 100 μg LSD and placebo in two resting-state fMRI sessions. We compared EC against whole-brain functional connectivity (FC) using classical statistics and machine...
Serotonergic hallucinogens presumably produce overall similar acute subjective (Hollister and Hartman, 1962; Wolbach et al, 1962) and potential therapeutic effects in humans. The early clinical trials used mostly LSD while most of the recent hallucinogen studies used psilocybin because of its ease of ...
27.Dos Santos RG,Osorio FL,Crippa JA,Riba J,Zuardi AW,Hallak JE (2016).Antidepressive,anxiolytic,and antiaddictive effects of ayahuasca, psilocybin and lysergicacid diethylamide(LSD):a systematic review of clinical trials published in the last 25years.Ther Adv Psychopharmacol 6:193‑213. 28....
LSD1/KDM1A inhibitors in clinical trials: advances and prospects. J Hematol Oncol. 2019;12(1). 38. Lu Y, et al. LncRNA HAS2-AS1 Promotes Glioblastoma Proliferation by Sponging miR-137. Front Oncol. 2021;11:634893. 39. Singh MM, et al. Inhibition of LSD1 sensitizes glioblastoma ...
LSD1/KDM1A inhibitors in clinical trials: advances and prospects. J Hematol Oncol. 2019;12(1). 38. Lu Y, et al. LncRNA HAS2-AS1 Promotes Glioblastoma Proliferation by Sponging miR-137. Front Oncol. 2021;11:634893. 39. Singh MM, et al. Inhibition of LSD1 sensitizes glioblastoma ...
Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified nuclear protein with histone demethylase activity. In particular, it plays a special role in the epigenetic regulation of gene expression, as it removes methyl gro
Finally, we confirmed these results in a more clinically relevant context, using T cells derived from pmel-1 TCR–Tg mice and specific for the self/tumor antigen gp100, which has been targeted also in human clinical trials47. Pmel-1 CTL were first skewed ex vivo towards a memory phenotype...