The new substance, however, aroused no special interest in our pharmacologists and physicians; testing was therefore discontinued. For the next five years, nothing more was heard of the substance LSD-25. Meanwhile, my work in the ergot field advanced further in other areas. Through the ...
Since both LSD and psilocybin primarily act on 5-HT2A receptors, an increasing number of clinical trials using psychedelics have been registered to evaluate their efficacy for treatment of depressive disorders and other psychiatric conditions [9]. Given this clinical potential and growing interest in ...
In one 2020 systematic review from Spain, researchers evaluated controlled and randomized clinical trials. The authors used the Cochrane Collaboration Tool to assess studies for risk of bias, and 11 studies were selected. LSD was administered to 567 patients in a dose that ranged from 20 micrograms...
Although more than seven inhibitors are going through different phases of clinical trials27, the mechanism of action of LSD1 inhibitors remains underexplored. Several LSD1 inhibitors have been shown to target the stability or protein interacting capability of LSD1 in addition to the demethylase ...
The study was registered at ClinicalTrials.gov (NCT01878942). All of the subjects provided written informed consent and were paid for their participation. The present clinical study also assessed additional acute subjective, autonomic, adverse, endocrine, and pharmacokinetic effects of LSD as reported ...
The first data has been announced from a Phase 2 trial testing LSD as treatment for anxiety. The results indicate one to two LSD sessions can generate rapid and sustained reductions to anxiety but larger trials are needed to validate these findings.
Anxiety: MDMA has been used in clinical trials to help patients with social anxiety, particularly those with autism, facilitating more comfortable and effective social interactions. Couples Therapy: Relationship Therapy: MDMA has been explored for use in couples therapy to improve communication and emoti...
Uniformity test maps are defined as z-scores from a one-way ANOVA testing whether the proportion of studies that report activation at a given voxel differs from the rate that would be expected if activations were uniformly distributed throughout gray matter. Here, we correlated each brain states...
The participants needed to adjust to the altered state of consciousness; therefore, testing occurred after a ‘plateau phase’ was reached. Nevertheless, at the time of testing, the subjective effects and plasma concentrations of LSD were still at approximately 50% of the peak responses and ...
The studies were all registered at ClinicalTrials.gov (Study 1: NCT01878942; Study 2: NCT02308969; Study 3: NCT03019822; Study 4: NCT03321136). The studies included a total of 84 healthy subjects. Study 125 and Study 417 each included 16 subjects. Study 2 included 24 subjects26. Study 3...