Takagi and Takaori (10, 11) analysed the mode of action of chlorpromazine, diethazine and promethazine on the central nervous system with the aid of various evoked potentials following stimulation of the peripheral nerves and central nervous structures, and spinal reflex discharges. Yamamoto (12) ...
there was no effect of LSD 25 on the telencephalically induced attention response while chlorpromazine has a clear blocking effect under the same experimental circumstances, it seems no longer correct to consider these two psychotropic drugs as having any simple opposite effect on nervous system ...
Instead, perturbation of LSD1 isoforms that are devoid of the neurospecific exon elicits no morphogenic effect. Collectively, results demonstrate that the arousal of neuronal LSD1 isoforms pacemakes early neurite morphogenesis, conferring a neurospecific function to LSD1 epigenetic activity. 展开 ...
The effect of LSD on the slow wave activity of the rabbit hippocampus and on hippocampal unit firing was studied. High doses of LSD (up to 0.1 mgm/kgm) abolish both the slow wave activity and the unit firing. In some experiments there was a clear correlation between EEG and unit activity...
How does Mg2+ block the effect of extracellular calcium on neurotransmitter release? How does the parasympathetic nervous system affect ft R? What neurotransmitter is involved? What Cranial Nerve is involved? What is activated by renin? What are the stimuli for the release of: Which neural pathway...
4, 5-dimethoxycanthin-6-One had a slight inhibitory effect on HKF cell lines activity (Additional file 2: Fig. S2). The viability results combined with the LSD1 enzyme assay, qRT-PCR and western blot results indicated that 4,5-dimethoxycanthin-6-one effectively inhibited LSD1 activity ...
OR10G2 knockdown had no effect on CD11b expression level (Fig. 4B). Next, we performed cell counting and MTT assays whether cell proliferation changes caused by OR10G2 knockdown (Fig. 4C and D). Importantly, the growth of stable OR10G2 knockdown HL-60 cells was significantly lower ...
This communication describes experiments confirming meiotic aberrations in the germinal cells of mice injected with LSD and compares the effects of the drug on the ... MM Cohen,AB Mukherjee - 《Nature》 被引量: 54发表: 1968年 The Effect of LSD-25 on the Chromosomes of Children Exposed in ...
Effects on the Body: LSD: Sympathetic Nervous System: LSD stimulates the sympathetic nervous system, which can cause increased heart rate, blood pressure, and body temperature. It may also lead to dilated pupils and mild sweating. MDMA: Cardiovascular System: MDMA can significantly increase heart ...
In addition, we all know that the protein level is usually balanced under the regulatory effect of some ubiquitinating enzymes, deubiquitinating enzymes, methyltransferases, acetylases, deacetylases, and phosphorylases. Next, we highlighted the impact of these enzymes on LSD1 protein levels. It is ...