While today research on important projects is almost exclusively carried out as teamwork, the investigations on ergot alkaloids described above were conducted by myself alone. Even the further chemical steps in the evolution of commercial preparations remained in my hands—that is, the preparation of...
Interestingly, LSD1 also affects the activity of the first identified tumor suppressor protein, the product of the retinoblastoma gene (RB1), which leads to arrest in the G1phase of the cell cycle82. pRB acts in concert with another key regulator of cell cycle progression, the transcription f...
Since our in vitro data showed that GSE1 acts as a corepressor of genes linked to inflammatory, immune-response and myeloid-differentiation pathways, we analysed the RNA-seq profiles from both datasets to identify genes whose expression levels negatively correlate with GSE1. Indeed, we found that...