Psychopharmacology of HallucinogensMartin W. R., Vaupel D. B., Sloan J. W., Bell J. A., Nozaki M. and Bright L. D. (1978a) The mode of action of LSD-like hallucinogens and their identification, in The Psychopharmacology of Hallucinogens (Stillman R. C. and Willette R. E., eds.)...
The craze for psychedelics used for therapeutic purposes is real. However, the scientific evidence supporting their effectiveness and explaining their mode of action in treating mental health disorders is still very thin. A new study led by Dr. Gabriella Gobbi, a senior scientist in the Brain Repa...
Mode of action of LSD on serotonergic neurons Much evidence has now accumulated that D-lysergic acid diethylamide (LSD) can produce profound alterations in the biochem-istry and physiology of serotonergic neurons in brain. Originally, the hypothesis that LSD might produce its effect... GK Aghajani...
the acquisition of immune tolerance via a balanced immune cell composition, and maturation of the intestinal epithelium. While studies have uncovered an interplay between the first two, less is known about the role of the maturing epithelium. Here we show that intestinal-epithelial intrinsic...
However, the complete understanding of their complex mechanism of action is still unreached. Here, we unraveled a novel mode of action of the LSD1 inhibitors MC2580 and DDP-38003, showing that they can induce differentiation of AML cells through the downregulation of the chromatin protein GSE1....
Default Mode Network: LSD disrupts the default mode network (DMN), a network of brain regions associated with self-referential thoughts and ego. This disruption can lead to a sense of ego dissolution and altered self-awareness. Body: Sympathetic Nervous System: LSD stimulates the sympathetic nervou...
Fan Central Current
The expression of PLZF-RARα as well as the reciprocal RARα-PLZF protein both appear to contribute to leukemogenesis. While the mode of action of PML-RARα has been studied in detail, less is known about transcriptional repression mediated by PLZF-RARα. We and others previously showed an ...
Acute LSD administration significantly decreased functional connectivity within visual, sensorimotor and auditory networks and the default mode network. While between-network connectivity was widely increased and all investigated networks were affected to some extent, seed-to-voxel analyses consistently ...
115.Sewell RA,Halpern JH,Pope HG,Jr.(2006).Response of cluster headache topsilocybin and LSD.Neurology 66:1920‑1922. 116.Speth J,Speth C,Kaelen M,Schloerscheidt AM,Feilding A,Nutt DJ,et al.(2016).Decreased mental time travel to the past correlates with default‑ mode network...