These results suggested that CNP suppressed LPS-induced inflammatory response by decreasing permeability of intestinal epithelial monolayer and secretion of pro-inflammatory cytokine in Caco-2 cells, which were partially mediated by NF-κB signaling pathway....
(2006) HMGB1 is secreted by im- munostimulated enterocytes and contributes to cy- tomix-induced hyperpermeability of Caco-2 mono- layers. Am. J. Physiol. Cell Physiol. 290:C990–9. 10. Aneja RK, et al. (2008) Preconditioning with high mobility group box 1 (HMGB1) induces ...
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It also significantly increased TEER value and decreased paracellular permeability of Caco-2 cells stimulated by LPS. B. longum subsp. longum K5 (MOI 1:100) up-regulated ZO-1, occlaudin and claudin-1 mRNA expression, down-regulated the mRNA expression level of TLR4 and pro-inflammatory ...
Cytoskeletal regulation of Caco-2 intestinal monolayer paracellular permeability[J]. J Cell Physiol. 1995;164(3):533–45. Article CAS Google Scholar Madara JL, Barenberg D, Carlson S. Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: further evidence that the ...
胞如内皮细胞和表皮细胞,LPS 与血清中SCDI4 结 BPI (bactericidal permeability-increaSing protein )合,再与细胞膜上的受体结合将信号转导到细胞内。 是一种分子量约55 kD 的阳离子分泌蛋白,BPI 并不 CDI4 与多种传递信号的跨膜信号受体不同,没有跨 是LPS 的结合受体,但BPI 与LPS 的结合能力较强, 膜区...
SGLT-1-transfected Caco-2 cells were treated with LPS (50 mug/mL) in low (5 mM) or high (25 mM) glucose media. LPS in low glucose induced caspase-3 cleavage, DNA fragmentation, and increased paracellular permeability to dextran in epithelial cells. These phenomena were significantly ...
pressionofTLR4/NF⁃κBsignalingpathwayinLPS⁃stimulatedCaco⁃2cells[J].MicrobialPathogenesis,2018,116:313317. [11]STEPHENSM,VONDERWEIDPY.Lipopolysaccharidesmodulateintestinalepithelialpermeabilityandinflammationina - species⁃specificmanner[J].GutMicrobes,2020,11(3):421432. [12]吕明其,闵思明,衣伟萌...
Some dietary constituents, such as gliadin36, has the potential to increase gut permeability which, again, could be associated with increased LPS absorption. Due to a small number of individuals adhering to a gluten-free diet, we were not able to address this issue in the current analyses. ...
However, unhealthy dietary practices such as overeating and consuming high-calorie foods lead to an imbalance of intestinal microorganisms, increased intestinal permeability, and LPS transport to the human circulatory system, resulting in periodic exacerbation of low levels of inflammation (Ruiz-Núñez ...