(B) Estimated fraction of TP53-mutated (TP53-mut) (red line) and TP53-wt cells (green line) before therapy, during remission and after TP53-mut/cnLOH expansion in relapse in patient 1507. Bars, NGS result (right y-axis). (C) Number of mutations before therapy and during relapse. ...
To transform grid cell-level estimates into a range of information useful to a wide constituency of potential users, estimates were aggregated at first and second administrative units specific to each country and at national levels73. Although the models can predict all locations covered by available...
such as in HIV12 or some malignancies; because there are hormonal imbalances, such as with chronic inflammation;13 or due to increased demand (such as during pregnancy), nutrient malabsorption or inadequate supply of red blood cell building blocks, such as protein, iron, vitamin A14, folate or...
Neoantigen-specific T cell reactivity in MMR-p CRC.aIFN-γ production of expanded TIL in response to synthetic long peptides (SLP) and synthetic short peptides (SSP), potential neo-epitopes in red and non-recognized peptides in black. SEB (gray) and DMSO (white) were taken along as posi...
We used several parameters, CD, chemo cell ratio (CCR) and chemo index (CI) to evaluate the chemotactic function of neutrophils more comprehensively. It was difficult to isolate enough LDNs from the peripheral blood of healthy controls to complete chemotactic experiments. The chemotactic ability of...
Exclusive breastfeeding (EBF)—giving infants only breast-milk for the first 6 months of life—is a component of optimal breastfeeding practices effective in preventing child morbidity and mortality. EBF practices are known to vary by population and c
and underwent enzymatic digestion using a Tumour Dissociation kit (Miltenyi Biotec) and gentle MACS Dissociator (Miltenyi Biotec) to obtain single-cell suspension. After centrifugation at 300 × g, both tumour-derived cells and ascites underwent red blood cell removal using Red Blood Cell Lysis...
Metronomic Chemotherapy with Low-Dose Cyclophosphamide plus Gemcitabine Can Induce Anti-Tumor T Cell Immunity in Vivo. Cancer Immunol. Immunother. CII 2013, 62, 383–391. [Google Scholar] [CrossRef] Sharabi, A.; Laronne-Bar-On, A.; Meshorer, A.; Haran-Ghera, N. Chemoimmunotherapy ...
A blood–brain barrier (BBB) opening was performed using a 1 MHz preclinical ultrasound system in combination with 10 µL/g microbubbles. Brain penetration of immune checkpoint inhibitors was determined, and immune cell populations were evaluated using flow cytometry. The impact of repeated ...
We think that this patient would have recurred irrespective of SLN micrometastatic involvement. Again, the coexistence of multiple high-risk factors makes it impossible to assess the true impact of LVM on prognosis. Table 1. Exploration of the available literature: study design, population, and ...