To explore the effect of beta-adrenergic blockade on low heart rate-related (mental stress) ischemia, 19 patients with coronary artery disease were randomized into a double-blind crossover trial of metoprolol, 100 mg twice daily, and underwent serial mental stress/bicycle exercise studies. Mental ...
To explore the effect of beta-adrenergic blockade on low heart rate-related (mental stress) ischemia, 19 patients with coronary artery disease were randomized into a double-blind crossover trial of metoprolol, 100 mg twice daily, and underwent serial mental stress/bicycle exercise studies. Mental ...
As we know, amiodarone slows conduction rate and prolongs the refractory period of the SA and AV nodes;23 propafenone slows the influx of sodium ions into the cardiac muscle cells, causing a decrease in excitability of the cells;24 and metoprolol blocks β1 adrenergic receptors in heart muscle...
Impact of Carvedilol and Metoprolol on Inappropriate Implantable Cardioverter-Defibrillator Therapy: The MADIT-CRT Trial (Multicenter Automatic Defibrillat... Objectives The goal of this study was to evaluate the effects of carvedilol and metoprolol on the endpoint of inappropriate implantable cardioverter-...
Intravenous metoprolol targeting a heart rate ≤60 beats/min was administered in patients whose heart rate exceeded 65 beats/min 3 min after the suspension of the adenosine infusion. All patients received 0.5 mg of sublingual nitroglycerin before the rest scan. The latter was acquired 10 min ...
An experimental run consisted of baseline, stimulation (10 minutes), and recovery (5 minutes), repeated 3 times before and after β1- receptor blockade (BB, metoprolol). ResultsARP stimulation produced significant increases in cardiac function reflected by elevated LVP, LV, dP/dtmax, and reduced...
When heart rate was higher than 70 beats/min, the administration of beta-blockers (at least 50 mg of metoprolol) was recommended in order to obtain heart rates <60 beats/min prior to CT scanning. In subjects randomised to undergo cardiac CT only, standard prospectively ECG-triggered ...
Luzier AB, Killian A, Wilton JH, Wilson MF, Forrest A, Kazierad DJ (1999) Gender-related effects on metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers. Clin Pharmacol Ther 66(6):594–601 Article CAS Google Scholar Magalon H, Patin E, Austerlitz F, Hegay T, Aldashev A...
During propranolol treatment epinephrine induced a marked pressor effect at all rates. There was a considerable rise in systolic as well as in diastolic blood pressure and heart rate fell. During metoprolol treatment there was only a slight rise in blood pressure and heart rate rose. Forearm ...
metoprololhypertensionheart rateSibutramine is an effective appetite suppresser agent, but treatment is often complicated with side effects, including palpitations and hypertension. In this study, we aimed to assess the effect of low-dose cardio-selective beta blocker combination with sibutramine treatment...