Mutant p53 proteins: between loss and gain of function. Head Neck 2007; 29: 488-496.Strano S, Dell'orso S, Mongiovi AM, et al. Mutant p53 proteins: Between loss and gain of function. Head Neck. 2007;29(5):488-496.Mutant p53 proteins: Between loss and gain of function[J] . ...
For gain-of-function mutations, we calculate the probability of mutant fixation starting from one mutant cell. For loss-of-function mutations, we calculate the rate of production of double-hit mutants. It turns out that the results are different in all models. This suggests that simple mass-...
gain-and loss-of-function mutations in zat10 enhance the tolerance of plants to abiotic stress R Mittler,Y Kim,L Song,... 被引量: 0发表: 2017年 Systemic and Intracellular Responses to Photooxidative Stress in Arabidopsis As the sun tracks daily through the sky from east to west, different...
Gain-of-function mutation has not been frequently observed in rice plants, thus, the mutants can be used to identify loci of novel genes for the regulation of disease resistant response. 展开 关键词: Gain-of-function gamma-ray loss-of-function rice mutants ...
Homozygous dACOX1ywg mutants die as pupae, and no escapers are observed (Figure 1B; 0/859 expected progeny). For the second loss-of-function allele, we introduced attP-FRT-SA-T2A-Gal4-polyA-3xP3-EGFP-polyA-FRT-attP (T2A-GAL4) into the first coding intron of dACOX1, referred to as ...
Certain mutations in the Deadend1 (Dnd1) gene are the most potent modifiers of testicular germ cell tumor (TGCT) susceptibility in mice and rats. In the 129 family of mice, the Dnd1 Ter mutation significantly increases occurrence of TGCT-affected males.
To identify functional domains in the CheZ protein, we made mutants by random mutagenesis of the cheZ gene and constructed a series of deletions. The map position and the in vivo and in vitro activity of the resulting gain- or loss-of-function mutant proteins define separate functional domains...
Mutations can be induced by various physical and chemical agents or can occur spontaneously without any artificial treatment with known mutagenic agents. Until the discovery of x-rays as mutagens, all the mutants studied were spontaneous in origin; that is, they were obtained without the deliberate...
L. et al. A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity. PLoS One 9, e110226 (2014). Article Google Scholar Hanoune, J. & Defer, N. Regulation and role of adenylyl cyclase isoforms. Annu. Rev. Pharmacol. Toxicol. 41, 145–174 (2001). ...
CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants Article25 January 2021 A novelNONOvariant that causes developmental delay and cardiac phenotypes ArticleOpen access18 January 2023 A homozygous nonsense mutation inDCBLD2is a candidate cause of de...