Mechanistic studies found that ritonavir also inhibits CYP3A4 which is now known as the main mechanism of the drug's action. Currently, it is used in the treatment of HIV in a co-administration program of anti-retroviral drugs (Clevenbergh et al., 2002; Walmsley et al., 2002). • ...
Food and Drug Administration to approve of the protease inhibitor drug lopinavir/ritonavir (Kaletra). Use of the drug in the treatment of HIV infection; Mechanism of action; Details on drugs to be avoided with Kaletra.MohamedFazilA.Osborne
Developer Abbott Laboratories; AbbVie; University of Alberta Class Amides; Antiretrovirals; Carbamates; Pyrimidinones; Small molecules; Thiazoles Mechanism of Action HIV protease inhibitors Orphan Drug Status Orphan designation is assigned by a regulatory body to encourage companies to develop drugs...
Despite the clinical use of these two drugs, no information regarding their possible mechanism of action at the molecular level is still known for SARS-CoV-2. Very recently, the crystallographic structure of the SARS-CoV-2 main protease (M), also known as C30 Endopeptidase, was published. ...
lopinavir is the phosphate salt of chloroquine, a quinoli compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully und...
signs of a nerve problem known asGuillain-Barre Syndrome(such as difficulty breathing/swallowing/moving your eyes, drooping face,paralysis, slurred speech), increased thirst, increased urination, confusion, persistent nausea or vomiting, stomach or abdominal pain, ...
As the mechanism of action of NFV to overcome PI resistance likely involves additional mechanisms besides ABCB1 inhibition, we aimed to establish the specific contribution of the ABCB1-mediated vs ABCB1-independent role of NFV or LPV against MM. In the presence of functional ABCB1, LPV or NFV...
These results open the possibility for the use of HIV-PIs as a tangible alternative in the treatment of Chagas' disease. However, the main mechanism of action of nelfinavir and lopinavir has yet to be elucidated, and more studies usingin vivomodels must be conducted....
action mechanismSevere acute respiratory syndrome 2 (SARS-CoV-2) caused the emergence of the COVID-19 pandemic all over the world. Several studies have suggested that antiviral drugs such as favipiravir (FAV), remdesivir (RDV), and lopinavir (LPV) may potentially prevent the spread of the ...