Presents information on the decision of the U.S. Food and Drug Administration to approve of the protease inhibitor drug lopinavir/ritonavir (Kaletra). Use of the drug in the treatment of HIV infection; Mechanism of action; Details on drugs to be avoided with Kaletra.Mohamed...
Developer Abbott Laboratories; AbbVie; University of Alberta Class Amides; Antiretrovirals; Carbamates; Pyrimidinones; Small molecules; Thiazoles Mechanism of Action HIV protease inhibitors Orphan Drug Status Orphan designation is assigned by a regulatory body to encourage companies to develop drugs...
Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavirSARS-CoV-2PROTEASE inhibitorsLOPINAVIR-ritonavirNELFINAVIRENDOPEPTIDASESMOLECULAR dynamicsCoronavirus SARS-CoV-2 is a recently discovered single-stranded RNA ...
200 mg lopinavir, 50 mg ritonavir: Yellow, film-coated, ovaloid, debossed with the “a” logo and the code KA containing 200 mg lopinavir and 50 mg ritonavir. Tablets, 100 mg lopinavir, 25 mg ritonavir: Pale yellow, film-coated, ovaloid, debossed with the “a” logo and the code KC...
HIV/AIDS: Ritonavir is the second FDA approved drug for the treatment of HIV. It was originally designed to suppress HIV protease. Mechanistic studies found that ritonavir also inhibits CYP3A4 which is now known as the main mechanism of the drug's action. Currently, it is used in the treat...
Antiretroviral; fixed combination of 2 HIV protease inhibitors (PIs): lopinavir and ritonavir (lopinavir/ritonavir). Ritonavir, a CYP3A inhibitor, is included in the fixed combination to increase plasma concentrations of lopinavir.Uses for Lopinavir and Ritonavir...