Long-chain fatty acyl-CoA synthetases (ACSLs), a group of rate-limiting enzymes in fatty acid metabolism, catalyze the bioconversion of exogenous or de novo synthesized fatty acids to their corresponding fatty acyl-CoAs. In this study, systematical analysis of ACSLs levels and the amount of ...
The Fatty Acyl-CoA Synthetases☆ Long-Chain ACSs The most abundant FAs in nature contain 16–18 carbons; thus, many ACS studies have focused on the long-chain (ACSL) enzyme family members. These enzymes typically utilize FA substrates containing 8–20 carbon atoms. It should be recognize...
Fatty acids (FAs) must be esterified by fatty acyl-CoA synthetases to form biologically active acyl-CoA in order to enter the anabolic and/or catabolic pathway. Long-chain acyl-CoA synthetase 4 (ACSL4) is associated with female reproduction. However, whether it is involved in decidualization ...
Long-chain acyl-CoA synthetases (ACSLs) are key host-cell enzymes that convert fatty acids (FA) into acyl-CoA for use in metabolic pathways. Here, we show that the complete host ACSL family [ACSL1 and ACSL3–6] translocates into the Ct membrane-bound vacuole, termed inclusion, and ...
Long-chain acyl-CoA synthetase FadE: Acyl-CoA dehydrogenase FadH: 2,4-Dienoyl-CoA reductase FadL: Long-chain fatty acid transport protein Fas: Fatty acid synthase (bacteria type) NMS: Neonatal maternal separation PCoA: Principal coordinate analysis SLCFAs: Saturated long-chain fatty acids...
(FC)was鈮 0.5 and鈮 2.RESULTS We found that three FA transporters and two long-chain acyl-CoA synthetases genes were significantly upregulated in the PDAC tissue compared to the non-tumoral tissue:SLC27A2(FC=5.66;P=0.033),SLC27A3(FC=2.68;P=0.040),SLC27A4(FC=3.13;P=0.033),ACSL1(FC=...
739-750Heterogeneous Long Chain Acyl-CoA Synthetases ControlDistribution of Individual Fatty Acids in Newly-FormedGlycerolipids of Neuronal Cells UndergoingNeurite OutgrowthJianxue Li1 and Richard J. Wurtman1,2(Accepted December 16, 1998)Using PC12 cells undergoing neurite outgrowth, we studied the ...
Long-chain acyl-CoA synthetase FadE: Acyl-CoA dehydrogenase FadH: 2,4-Dienoyl-CoA reductase FadL: Long-chain fatty acid transport protein Fas: Fatty acid synthase (bacteria type) NMS: Neonatal maternal separation PCoA: Principal coordinate analysis ...
However, the directionality of this channeling may also depend on the association of each of the five acyl-CoA synthetase isoforms with specific protein partners. Long-chain acyl-CoA synthetases (ACSLs) catalyze the conversion of long-chain fatty acids to fatty acyl-CoAs, which are then either ...
Very long chain acyl-CoA synthetases (ACSVL) also possess some activity toward long chain fatty acids. Similar to the ACSL splice variants, triacsin C sensitivity has not been tested in many of the ACSVL isoforms. Additional research is needed to further characterize other ACSL variants or ACS...