Long-term citalopram more effective, less costly than standard therapy?doi:10.1007/BF03309738NonePharmacoEconomics & Outcomes News
摘要: Presents a results of the study on citalopram, a selective serotonin reuptake inhibitor. Its effectiveness for the treatment of panic disorder; Methodology of the study; Recommended dosage of citalopram on patients with panic disorder.
Acute and long-term administration of citalopram desensitizes α2-adrenoceptors in the rat vas deferens Journal of Pharmacy & PharmacologyLaura GrandosoLaura GarcíaJoseba PinedaLuisa Ugedo
Side effects were similar to those reported from the use of other selective serotonin reuptake inhibitors (SSRIs). No patient was excluded because of serious side effects during the 1 year of observation. The clinical effectiveness and tolerability of citalopram in the long-term treatment seem to ...
An increased risk of suicidal thinking and behavior in children, adolescents, and young adults (aged 18 to 24 years) with major depressive disorder (MDD) and other psychiatric disorders has been reported with short-term use of antidepressant drugs....
Overall, this study provides that citalopram at the recommended human doses after long-term treatment is genotoxic for mouse germ cells. Thus, male patients receiving citalopram may stand at higher risk for abnormal reproductive outcomes, particularly in the reproductive ages. Highlights ► Citalopram...
Rationale: The discriminative stimulus (DS) properties of the selective serotonin (5-HT) uptake inhibitor (SSRI), citalopram, are mediated by 5-HT2C receptors. Interestingly, the "atypical" antidepressants, mianserin and mirtazapine, behave as antagonists at 5-HT2C receptors. Objective: Herein,...
Anyone considering the use of citalopram hydrobromide or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond ...
Placebo appears to be a good comparator in assessing the long-term efficacy of antidepressants. For example, in an assessment of the long-term efficacy of citalopram, patients who responded while taking placebo and were continued on placebo treatment were compared with patients who responded to ...
The National Institute for Health Research-funded study involved 478 primary care patients in England who had been taking long-term antidepressants (citalopram, sertraline, fluoxetine, or mirtazapine) and who felt well enough to consider stopping. 70% had been taking the medication for more than thr...