Citalopram, a selective serotonin re-uptake inhibitor: clini- cal antidepressive and long-term effect - a phase II study. Psychopharmacology 1982 ; 77 : 199-204.Pedersen OL, Kragh-Sørensen P, Bjerre M, Fredricson Overa K. Gram LF. Citalopram, a selective serotonin reuptake inhibitor: ...
Examines the effects of long-term treatment with the selective serotonin reuptake inhibitor citalopram or clomipramine on subjective phobic symptoms in pat... Leinonen,Esa,Lepola,... - 《Journal of Psychiatry & Neuroscience》 被引量: 46发表: 2000年 Medication treatments for panic disorder and soci...
Both PhACs impaired the cholinergic pathway long-term, even after the depuration period, as indicated by decreased AChE levels in the gills, suggesting potential neurotoxic effects after prolonged exposure. Consequently, adverse effects were provoked by both PhACs with (CIT) and without (BEZ) ...
Objective: Herein, we evaluated the influence of mianserin and mirtazapine upon the DS effects of citalopram. Methods: In a two-lever drug discrimination procedure, rats initially trained to discriminate citalopram (2.5 mg/kg, i.p.) from saline were retrained with a lower dose of citalopram (...
Overall, this study provides that citalopram at the recommended human doses after long-term treatment is genotoxic for mouse germ cells. Thus, male patients receiving citalopram may stand at higher risk for abnormal reproductive outcomes, particularly in the reproductive ages. Highlights ► Citalopram...
In two long-term studies, patients with MDD who had responded to citalopram during an initial 6 or 8 weeks of acute treatment were randomized to continuation of citalopram or placebo. In one study, patients received fixed doses of citalopram 20 mg or 40 mg daily and in the second study, ...
No patient was excluded because of serious side effects during the 1 year of observation. The clinical effectiveness and tolerability of citalopram in the long-term treatment seem to be comparable with the observations of other SSRIs in childhood and adolescent OCD. A further, statistically ...
A case-control study in Israel compared 280 infants of nursing mothers taking long-term psychotropic drugs to the infants of 152 women taking antibiotics. Infant sleepiness at 4 days of age was reported by 1 mother taking citalopram during pregnancy and breastfeeding and by none taking antibiotics...
Initial treatment for most adults will begin at 20 mg once a day, and may be increased to 40 mg a day depending on the nature of the patient's condition and how long the patient expects to take the medication. Those who are planning on long-term use will need to use lower doses to...
The present study was undertaken to compare the acute and long-term effects of escitalopram and citalopram on rat brain 5-HT neurotransmission, using electrophysiological techniques. In hippocampus, after 2 weeks of treatment with escitalopram (10 mg/kg/day, s.c.) or citalopram (20 mg/kg/...