Gastroesophageal reflux disease (GERD) is one of the most common disorders of the gastrointestinal tract. Clinical presentation can vary from simple heartburn to erosive esophagitis. Some patients require long-term, possibly life-long, therapy. The cost of treatment is substantial, as patients with ...
Proton pump inhibitors (PPIs) are central in the management of GERD and are unchallenged with regards to their efficacy. They are considered safe and more effective than histamine receptor antagonists for healing esophagitis and for preventing its recurrence using a long term maintenance ...
PPIs have better characteristics for the long-term treatment of GERD, because they have a long-lasting, strong effect of raising intragastric pH and have... Y Kinoshita,K Adachi,H Fujishiro - 《Journal of Gastroenterology》 被引量: 28发表: 2003年 GERD: Diagnosing and treating the burn Althoug...
Presents a study on the long-term outcome of medical and surgical therapies for gastroesophageal reflux disease. Difference between medical and surgical treatments in patients with gastroesophageal reflux disease; Annual incidence rate of esophageal adenocarcinoma in patients ...
Short-term safety and efficacy of TIF (EsophyX, EndoGastric Solutions) were demonstrated inprevious trialswith up to 12 months of follow-up. In the current study, Trad and colleagues evaluated the durability of these outcomes at 36...
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GERD and its sequela, Barrett esophagus, are strong risk factors for esophageal adenocarcinoma,5- 6 a malignancy that has nearly quadrupled in frequency during the past 2 decades.7 Medical treatment of GERD involves long-term administration of antacids and antisecretory agents,8 and patients in ...
Treatment of gastroesophageal reflux disease in adults: an individualized approach. Until the 1990s, most therapeutic trials in gastroesophageal reflux disease (GERD) focussed upon endoscopic lesions. In fact the correlation between patien... JP Galmiche,K Stephenson - 《Digestive Diseases》 被引量: 39...
Clinical situations requiring long term acid suppressants GERD is a lifelong disease. Cessation of therapy results in recrudescence of symptoms and/or erosive esophagitis but long-term spontaneous remission is low. The duration of treatment and consequences of therapy are not known. Currently, long te...
This article provides an overview of GERD and the issues that must be considered during the long-term management of the disease; literature concerning the long-term treatment of GERD with the proton pump inhibitor (PPI) pantoprazole is then reviewed. Long-term management issues in GERD In ...