Long QT syndrome (LQTS)is an uncommon disorder where yourhearttakes longer than usual to recover after each beat. It affects one in 5,000 people and can raise the risk of “torsades de pointes,” a type ofirregular heartbeatthat can be deadly. But there are treatments for it. Here’s ...
Long QT syndromeBrugada syndromeDrugsArrhythmiasSudden deathSCN5A gene-related channelopathies, long QT syndrome, and Brugada syndrome are well known; both cardiovascular and noncardiovascular drugs can have detrimental effects in these disorders.The mechanisms by which these drugs can be dangerous, ...
This review focuses on the available evidence about safe use of drugs in long QT syndrome type 3 and Brugada syndrome. Both syndromes are associated with malignant arrhythmias and mutations in the cardiac sodium channel gene SCN5A. Both cardiovascular and noncardiovascular drugs have the ability to...
Drugs to be avoided in patients with long QT syndrome:Focus on the anaesthesiological management Drugs to be avoided in patients with long QT syndrome: focus on the anaesthesiological management. World J Cardiol. 2013;5(4):87–93. Central... - 世界心脏病学杂志:英文版(电子版) 被引量: 0...
A risk assessment of drug-induced Long QT Syndrome (LQTS) associated with COVID-19 repurposed drugs was performed and compared to 23 well-known torsadogenic and 10 low torsadogenic risk compounds. Computer calculations were performed using pharmacokinetic and pharmacodynamic data, including affinity...
Rare (less than 0.1%): Aortic aneurysm, arteritis, bigeminy, bundle branch block, capillary fragility, cardiovascular disorder (mitral valve and circulatory disturbance), coronary artery disease, congestive heart failure, cyanosis, ECG QT prolonged, first-degree atrioventricular block, heart arrest, hema...
deep vein thrombosis, electrocardiogram ST segment depression, extrasystoles, first-degree atrioventricular block, muscle hemorrhage, heat stroke, myocardial ischemia, orthostatic hypertension, QT prolongation, supraventricular tachycardia, Torsade de pointes, venous thromboembolism, ventricular arrhythmias, ventricu...
Additionally, Kcnq1ot1 knockdown promoted QT interval prolongation via Kcnq1 gene inhibition. Transfection with small interfering RNA (siRNA) downregulated the level of those pyroptosis markers, reversed DNA fracture, ameliorated vimentin expression, and reduced Ca2+ overload. Silencing Kcnq1ot1 promoted...
Common (1% to 10%): Bradycardia, bundle branch block, first-degree atrioventricular block/atrioventricular block, conduction disorder, electrocardiogram QT prolonged, hypertension, orthostatic hypotension, sinus arrhythmia, sinus tachycardia Uncommon (0.1% to 1%): Abnormal electrocardiogram, chest discomfort/...
Common(1% to 10%): Chest pain, flushing/hot flush, hypertension, palpitation, QT-interval prolongation, vasodilatation Uncommon(0.1% to 1%): Angina pectoris, arrhythmia, congestive heart failure, generalized edema, hypotension, myocardial infarct, peripheral edema, postural hypotension ...