REVIEWOpenAccessThefunctionalroleoflongnon-codingRNAsandepigeneticsJinnengCaoAbstractLongnon-codingRNAs(lncRNAs)arenon-proteincodingtranscriptslongerthan200nucleotides.Thepost-transcriptionalregulationisinfluencedbytheselncRNAsbyinterferingwiththemicroRNApathways,involvingindiversecellularprocesses.Theregulationofgeneexpression...
Long Noncoding RNAs (lncRNAs) are defined as RNA transcripts longer than 200 nucleotides that play a crucial role in regulating gene expression, particularly in cancer biology. AI generated definition based on:Advances in Clinical Chemistry,2022 ...
Epigenetics in neurobehavioral disease SolveigLøkhammer, inEpigenetics in Human Disease (Third Edition), 2024 7.2.2.1Long noncoding RNA Longnoncoding RNAis a class of RNA discovered to be important in brain development and neurodevelopmental regulation [37]. Similar tomiRNA, there are several under...
12]. Initially, lncRNAs were considered as transcriptional “noise,” given their relatively low expression levels compared with mRNAs and their lack of protein-coding capacity [13]. However,
Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response Wojciech Barczak Simon M. Carr Nicholas B. La Thangue Nature Communications(2023) Characterization of lncRNAs involved in drought response in Betula platyphylla ...
Fig. 1: Biogenesis and cellular fates of long non-coding RNAs. a| Biogenesis of long non-coding RNAs (lncRNAs). Unlike mRNAs, many RNA polymerase II (Pol II)-transcribed lncRNAs are inefficiently processed4,5,113and are retained in the nucleus6,10,12,13,16(mechanisms of lncRNA nuclear ...
In recent decades, genome-wide studies have uncovered evidence for extensive transcription outside the regions of DNA that encode proteins [22]. Long noncoding RNA (lncRNA) transcripts are greater than 200 nucleotides (nt) in length and have the same structure as messenger RNAs (mRNAs), includi...
Head and neck cancer (HNC) ranks as the 6th most common malignancy across the world. Metastasis is a hallmark of cancer, primarily contributing to the relapse and poor prognosis of HNC. Recently, long noncoding RNAs (lncRNAs), previously considered as no
Long noncoding RNAs (lncRNAs) are non-protein coding transcripts regulating a variety of physiological and pathological functions. However, their implication in heart failure is still largely unknown. The aim of this study is to identify and characterize
The expression of MEG3 long noncoding RNA (lncRNA), which could interact with JARID2, was clearly increased during transforming growth factor-β (TGF-β)-induced EMT of human lung cancer cell lines. Knockdown of MEG3 inhibited TGF-β-mediated changes in cell morphology and cell motility ...