Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice. J. Immunol. 180: 361-371.DiLillo DJ, Hamaguchi Y, Ueda Y, Yang K, Uchida J, et al. (2008) Maintenance of long-lived plasma cells and serological ...
Humoral immunity due to long-lived plasma cells. Conventional models suggest that long-term antibody responses are maintained by the continuous differentiation of memory B cells into antibody-secreting pl... MK Slifka,R Antia,JK Whitmire,... - 《Immunity》 被引量: 1921发表: 1998年 Short-lived...
B cells that leave the GC can develop into memory B cells, short-lived plasma cells, or long-lived plasma cells. The latter ultimately migrate back ... AM Vale,HW Schroeder - 《Journal of Allergy & Clinical Immunology》 被引量: 140发表: 2010年 The thymus-independent immunity conferred by...
Antibody responses to viral infections are sustained for decades by long-lived plasma cells (LLPCs). However, LLPCs have yet to be characterized in humans. Here we used CD19, CD38, and CD138 to identify four PC subsets in human bone marrow (BM). We found that the CD19−CD38hiCD138...
Long-lived plasma cells are critical to humoral immunity as a lifelong source of protective antibodies. Antigen-activated B cells—with T-cell help—undergo affinity maturation within germinal centres and persist as long-lived IgG plasma cells in the bone marrow. Here we show that antigen-specific...
Memory B (B(MEM)) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity... MJ Benson,SR Dillon,E Castigli,... - 《Journal of Immunology》 被引量: 664发表: 2008年 Targeting B cells in immune-mediated inflam...
旦· 549·· 基础医学·长寿命浆细胞与系统性红斑狼疮侯金花综述章海涛审校摘要长寿命浆细胞可长期分泌抗体,产生保护性记忆,参与长期免疫,在自身免疫性疾病( 如系统性红斑狼疮) 中可持续产生自身抗体,使病情迁延反复复发。长寿命浆细胞主要存在于骨髓,在疾病状态下亦可在脾脏和炎症组织中发现,它能长期存活的原因与微...
Durable antibody immunity depends on long-lived plasma cells (LLPCs) that primarily reside in the bone marrow (BM). However, due to LLPC rarity, it has not been possible to define their phenotypes or determine their heterogeneity. By single-cell mRNA sequencing, cytometry and a genetic pulse...
Differentiation and maintenance of long-lived plasma cells. Curr Opin Immunol 2015;33:64-9.Kometani K, Kurosaki T: Differentiation and maintenance of long-lived plasma cells. Curr Opin Immunol 2015, 33c:64-69.Kometani K, Kurosaki T. Differentiation and maintenance of long-lived plasma cells. ...
The production of high-affinity antibodies by plasma cells and memory B cells generally requires the cognate interactions between B cells and T follicular helper (Tfh) cells within lymphoid tissues3. On this basis, the pathological relationship between B cells and Tfh cells has been a key focus ...