Once generated, memory B cells enter a resting state and persist over long periods of time in the lymphoid organs in the apparent absence of immunizing antigen. T cell-dependent (TD) B cell memory is generated along two fundamentally distinct differentiation pathways. One of these is the ...
B cells instruct their own fate through IL-12 Extrafollicular and germinal center reactions are considered to represent sequential phases of a primary B cell response. A study now demonstrates the ability of autocrine IL-12 to promote extrafollicular differentiation into plasmablasts, while inhibiting ...
From the regulatory functions of B cells to the identification of cytokine-producing plasma cell subsets. Curr. Opin. Immunol. 28, 77–83 (2014). Article CAS PubMed Google Scholar Gilbert, A. E. et al. Monitoring the systemic human memory B cell compartment of melanoma patients for anti-...
Memory B (B(MEM)) cells and long-lived bone marrow plasma cells (BM-PCs) persist within local environmental survival niches that afford cellular longevity. However, the factors supporting B(MEM) cell survival within the secondary lymphoid organs and allowing BM-PC persistence in the bone marrow...
Understanding how memory B cells are induced and relate to long-lived plasma cells is important for vaccine development. Immunity to oral vaccines has been considered short-lived because of a poor ability to develop IgA B-cell memory. Here we demonstrate that long-lived mucosal IgA memory is re...
Memory B cells Antigen-experienced B cells that express high-affinity antibodies and quickly differentiate into plasma cells in antigen-recall responses. Plasma cells Non-dividing, terminally differentiated, antibody-secreting cells of the B-cell lineage. ...
On the other hand, CD40 signaling increased the expansion of a B-cell pool from peripheral blood B cells primarily activated by IL-2, IL-10, and anti-CD40 monoclonal antibody (MoAb). Finally, CD27 signaling also rescued B cells from IL-10-mediated apoptosis. These data demonstrate that CD...
Humans respond to foreign antigen by generating plasma Abs and memory B cells (MBCs). The Ab response then declines, sometimes to below the limit of detection. In contrast, MBCs are generally thought to be long-lived. We tested and compared Plasmodium falciparum (Pf)-specific Ab and MBC resp...
He has received consultancy fees (paid to the university) from Alzheon, Brainstorm Cell, and Green Valley. Within his university, he is global PI of the phase 1b study of AC Immune, Phase 2b study with FUJI-film/Toyama, phase 2 study of UCB, and co-chair of the phase 3 study with...
Delayed SIV acquisition in vaccinated females correlated significantly with Env-specific memory B cell and PC levels in rectal tissue, 2 wks post-infection (P = 0.0011 and P < 0.0001, respectively). We have previously correlated vaccine-induced Env-specific secretory IgA with delayed SIV ...