Long-chain omega-3 fatty acid deficiency in mood disorders: rationale for treatment and prevention. Curr Drug Discov Technol 2013 September;10(3):233-44.McNamara RK. Long-chain omega-3 fatty acid deficiency in mood disorders: Rationale for treatment and prevention. Curr Drug Discov Technol. ...
5.2Very long chain fatty acids Peroxisomal disordersare characterized by impaired, reduced, or totalabsenceofperoxisomesin cells. These disorders imply an accumulation of verylong chain fatty acids(VLCFA) such as tetracosanoic andhexacosanoic acidsin plasma andred blood cells. Some vari...
Childhood adrenoleukodystrophy (cALD) is a metabolic disorder in which very long-chain fatty acids (VLCFA) accumulate due to ALD protein gene defects, ultimately leading to lipotoxicity-induced neuroinflammatory demyelinating disease. Therefore, we examined VLCFA-mediated alterations in the metabolism of ...
It is an autosomal recessive disorder caused by ACADVL variants, leading to impairment of the first intramitochondrial step of the catabolism of long-chain fatty acids.1 The incidence of VLCAD deficiency based on NBS reports varies among countries and regions, though much less than MCAD deficiency...
Patients with very long-chain acyl-CoA dehydrogenase (VLCAD) and long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD)/mitochondrial trifunctional protein (MTP) deficiency, disorders of the mitochondrial long-chain fatty acid oxidation, can present with hypoketotic hypoglycemia, rhabdomyolysis, and cardiomyop...
Role of long-chain omega-3 fatty acids in psychiatric practiceRole of long-chain omega-3 fatty acids in psychiatric practiceADHDAnxietyBipolar disorderCardiovascular diseaseClinical stagingDocosahexaenoic acid (DHA)Eicosapenaenoic acid (EPA)Long-chain omega-3 fatty acidsMajor...
Many clinical and animal studies demonstrate the importance of long-chain polyunsaturated fatty acids (LCPUFA) in neural development and neurodegeneration. This review will focus on involvement of LCPUFA from genesis to senescence. The LCPUFA docosahexaenoic acid and arachidonic acid are important compone...
An excess of intracolonic saturated long-chain fatty acids (SLCFAs) was associated with enhanced bowel motility in NMS rats. Heptadecanoic acid (C17:0) and stearic acid (C18:0), as the most abundant odd- and even-numbered carbon SLCFAs in the colon lumen, can promote rat colonic muscle ...
Long-chain 3-hydroxy acyl CoA dehydrogenase deficiency (LCHADD) (OMIM #609016) is an autosomal recessively inherited disorder of long-chain fatty acid oxidation with an estimated overall frequency of 1:50,000, first described in 1989 in children presenting with hypoketotic hypoglycemia and letharg...
Saturated long-chain fatty acid-producing bacteria contribute to enhanced colonic motility in rats Abstract Background The gut microbiota is closely associated with gastrointestinal (GI) motility disorder, but the mechanism(s) by which bacteria interact with and affect host GI motility remains unclear....