The present invention provides formulations of insulin or insulin analogs encapsulated in a liposome, and methods of producing such formulations. The invention further provides methods of treating hyperglycemia and related disorders by administering a formulation of the invention.Rimona Margalit...
Most pharmaceuticals are given using short-acting formulations that require frequent administration, which can negatively affect patient compliance and increase failure risks associated with inconsistent use. By contrast, long-acting release formulations can achieve sustained release of drugs for weeks, months...
A two-way crossover study was performed with insulin and glucose concentrations measured following subcutaneous administration of glargine once daily (0.5 U/kg) or twice daily (0.25 U/kg, repeated after 12 h). Nadir glucose concentration and mean daily glucose concentration did not ...
Insulin glargine has a slower onset of action than NPH insulin and a longer duration of action with no peak activity. Once-daily administration of ... TL Levien,DE Baker,JR White,... - 《Annals of Pharmacotherapy》 被引量: 114发表: 2002年 Basal insulin glargine (HOE 901) versus NPH ins...
Fig. 1: Schematic demonstrating traditional and data-driven formulation development approaches for long-acting injectables (LAIs). aSelected routes of administration for FDA-approved LAI formulations.bTypical trial-and-error loop commonly employed during the development of LAIs termed “traditional LAI fo...
45. Parker SD, Curry CS, Hirshman CA (1990) "A life-threatening reaction after propranolol administration in the operating room."Anesth Analg, 70, p. 220-1 46. Valsecchi R, Leighissa P, Piazzolla S, Naldi L, Cainelli T (1994) "Occupational contact dermatitis from propranolol."Contact Derm...
*Long-term melatonin administration improvesglucose homeostasis and insulin resistancestate in high-fat-diet fed rats1. IntroductionObesity is a common characteristic of type 2 diabetes,and is also a major contributing factor to insulinresistance, a hallmark feature of type 2 diabetes. Insulinresistance...
Objective-To determine the effects of short-term IV administration of hydrocortisone or equine growth hormone (eGH) or long-term IM administration of eGH to horses on tissue sensitivity to exogenous insulin. Animals-5 Standardbreds and 4 Dutch Warmblood horses. Procedure-The euglycemic-hyperinsulinemi...
exenatideveteransdiabetesinsulinanalogscohort Available online at ScienceDirect .sciencedirect Diabetes & Metabolism 40 (2014) 284–291 Original article Retrospective cohort study evaluating exenatide twice daily and long-acting insulin analogs in a Veterans Health Administration population with type 2 diabetes...
Rouzé et al Dovepress and progressive disease and requires multiple life-long therapies that require daily and time-consuming administration.3 Treatment generally comprises of the daily intake of pancreatic enzymes, nutritional supple- ments, airway clearance, physiotherapy, inhaled or nebu- lized ...