Long - acting formulations of insulinsBECKER REINHARD DRHAHN ANNKE DRBODERKE PETER DRFUERST CHRISTIANE DRMUELLER WERNER DRTERTSCH KATRIN DRWERNER ULRICH DRLOOS PETRA DRSCHOETTLE ISABELL
Pharmacologic and clinical studies on two new types of long-acting insulins with special reference to zinc insulin preparations (novo): a preliminary report. 来自 Semantic Scholar 喜欢 0 阅读量: 21 作者:JL Izzo,AM Gabig,J Hoffmaster 摘要: No abstract available.关键词: Insulin ...
Although the discovery of insulin 100 years ago revolutionized the treatment of diabetes, its therapeutic potential is compromised by its short half-life and narrow therapeutic index. Current long-acting insulin analogs, such as insulin-polymer conjugates, are mainly used to improve pharmacokinetics by...
The effects of insulin on cardiomyocytes, such as positive inotropic action and glucose uptake are well described. However, in vitro studies comparing long-acting insulin analogues with regard to cardiomyocyte signalling and function have not been system
[51,52]. Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as a new m6A reader protein, also increases the stability of its targeted RNA [53]. Taken together, m6A affects RNA stability, splicing, localization, and translation at the post-transcriptional level, as shown in Table...
The cis-acting refers to the regulation of genes in a host (in the case of ilncRNAs) or nearest neighboring protein coding genes (in the case of lincRNAs). According to the location of the lncRNAs and mRNAs on the chicken genome, 10/100 kb upstream or downstream of the differentially ...
Aims To conduct a comprehensive pre-clinical study of the novel ultra-long acting insulin analogue LAPS Insulin115. Methods Pharmacokinetic/pharmacodynamic studies comparing LAPS Insulin115 with other basal insulins were conducted in genetically diabetic ( db/db ) mice. Insulin signalling in the major...
NEAT1 lncRNA enhances angiogenesis by acting as ceRNA for miR-19-5p that targets TGB-βR2 and therefore enhancing VEGF-A expression. It also prevents resolving inflammation by inhibiting M2 macrophage polarization by acting ceRNA for miRNA-148a-3p that targets PTEN. The target sequences in PTEN...
LncRNAs acting like oncogenes, are up-regulated in tumor tissue. The metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) for example, which is expressed in human tissue, becomes up-regulated in various solid tumors, including liver, lung, breast and prostate cancer [30,60]. Some ...
Among the mAbs currently used for Ab-based cancer immunotherapy, trastuzumab, a human epidermal growth factor receptor (HER2) inhibitor used for early-stage and metastatic HER2+ BC and GC treatment [131], compiles a long list of lncRNAs whose expression dysregulation seems to interfere with its ...