[3].High throughput lipophilicity determination: Comparison with measured and calculated log P/log Dhttp://values.InB.Testa,H. van de Water- beemd, G.Folkers. & R.Guy (Eds.).Pharmacokinetic wptimiation in drug research: Biologicalphysiological. and computational srategies. Zurich: Verlag Helv...
[3].High throughput lipophilicity determination: Comparison with measured and calculated log P/log D values.In B.Testa,H. van de Water- beemd, G.Folkers. & R.Guy (Eds.).Pharmacokinetic wptimiation in drug research: Biologicalphysiolog...
[3].High throughput lipophilicity determination: Comparison with measured and calculated log P/log D values.In B.Testa,H. van de Water- beemd, G.Folkers. & R.Guy (Eds.).Pharmacokinetic wptimiation in drug research: Biologicalphysiological. and computational srategies. Zurich: Verlag Helvetica ...
B. Biomedical Sciences and Applicaions, 745,103-115. [3].High throughput lipophilicity determination: Comparison with measured and calculated log P/log D values.In B.Testa,H. van de Water- beemd, G.Folkers. & R.Guy (Eds.).Pharmacokinetic wptimiation in drug research: Biological...
[3].High throughput lipophilicity determination: Comparison with measured and calculated log P/log D values.In B.Testa,H. van de Water- beemd, G.Folkers. & R.Guy (Eds.).Pharmacokinetic wptimiation in drug research: Biologicalphysiological. and computational srategies. Zurich: Verlag Helvetica...
The Log P value is the logarithm of its partition coefficient between n-octanol and water, is a well-established measurement of a compound's hydrophilicity. Lipophilicity is a key factor for determining pharmacokinetic parameters such as permeation through a physical membrane, plasma protein binding,...
Lipophilicity is possibly the most important physicochemical property of a potential drug, it plays a role in solubility, absorption, membrane penetration, plasma protein binding, distribution, CNS penetration and partitioning into other tissues or organs such as the liver and has an impact on the ro...
I know log P means the ratio of concentrations of un-ionized compound between the two solutions. But if a drug with high log P, what does this really indicate? Will this affect the lipophilicity or any parameters? Thanks. Logged Dan ...
J. C. Correa & Gomes, L. N. L. F. Investigation of the Lipophilicity of Antiphlogistic Pyrazole Derivatives: Relationships Between Log Kw and Log P Values of 5-Arylamino and Arylhydrazono-3-Methyl-4-Nitro-1-Phenylpyrazoles, J. Liq. Chroma. 1991, 14, 1161-1171....
Log P是指在某一特定pH下，化合物在两相中全部以分子形式存在，测得化合物在有机相和水相中分配系数...