I know log P means the ratio of concentrations of un-ionized compound between the two solutions. But if a drug with high log P, what does this really indicate? Will this affect the lipophilicity or any parameters? Thanks. Logged Dan ...
In this paper we report on their lipophilicity evaluation combining computational and RP-HPLC experiments. A suitable computational method for the high-throughput log P screening was identified.doi:10.2174/157018006777805530O. Azzolina, S. Collina, D. Rossi, A. Carnevale Baraglia, S. Alcaro, A. ...
POCC possesses high lipophilicity and a high level of safety, resulting in better permeation enhancement effects in patches(Kováčik et al., 2020). The addition of any excipient in semi-solid Conclusions In this study, an optimized formulation containing 0.05 % MF cream was successfully developed...
To quantify the lipophilicity of PER, logP was measured in an octanol/ water system at 25°C, using standard shake flask methods. LogP values quantify how a solute distributes between oil and water phases and can therefore help to rationalize solubility data. The measured lo...
et al. Target-independent prediction of drug synergies using only drug lipophilicity. J. Chem. Inf. Model. 54, 2286–2293 (2014). Article CAS Google Scholar Preuer, K. et al. DeepSynergy: predicting anti-cancer drug synergy with Deep Learning. Bioinformatics 34, 1538–1546 (2018). ...
Although aqueous mobile phases were generally used with alkyl-bonded phase columns, due to thelipophilicityof TGs, water could not be used in themobile phasefor this particular application; therefore, the mobile phases generally employed consisted of mixtures of weak and str...
The calculated logarithm of the partition coefficient betweenn-octanol and water for a given compound. This parameter is an estimation of the lipophilicity of the compound. Combinatorial chemistry Rapid and parallel synthesis of large collections of compounds to facilitate the identification of new active...
K., 1993. A Comparison of methods for the determination of dead time in a reversed-phase high-performance liquid chromatography system used for the measurement of lipophilicity, J. of Liquid Chromatography 16(18), 3919 - 3932.NOWOTNIK D. P., NARRA R. K., "A comparison of methods for ...
Lipophilic ion-drug pairs can markedly increase solubility in lipidic phases through a combination of two mechanisms: (1) the lipophilicity of the counterion, which can help pull the drug into a lipid phase; and (2) the reduced crystalline forces (and Tm) of the ion-drug pair, which tends...
The lipophilicity of 9H-xanthene and 9H-thioxanthene derivatives, containing either a basic alkanamide or a nitrosoureido group, was studied by means of reversed-phase high-performance liquid chromatography using an octadecylsilane stationary phase, methanol as organic modifier and n-decylamine as ...