This method, known as cognitive restructuring, is a core aspect of cognitive behavioral therapy and can help you reshape your outlook more positively. Confronting these beliefs requires you to step out of your comfort zone and test the limits of your perceived control. Set small, manageable g...
It is defined as the belief in one's ability to impact change via action (Lefcour, 1991). These sets of beliefs will impact individuals' perspective on what happens around them and their control level over these things. There are two kinds of the locus of control: the internal and ...
Bearing in mind that the locus coeruleus (LC)-noradrenergic system regulates a plethora of processes, such as arousal, stress, cognition, and pain, it may be a critical hub driving the comorbidity of pain and stress-related disorders. With the recent development of powerful neuroscience tools, ...
For the protein quantitative trait loci (pQTLs) from blood, we either did not find the genes in the cohort or the number of SNPs within the gene was too low (<20) to test for colocalization (Supplementary Table 3). No variants were associated at genome-wide significance in the GWAS in...
Individuals may show different responses to stressful events. Here, we investigate the neurobiological basis of stress resilience, by showing that neural responsitivity of the noradrenergic locus coeruleus (LC-NE) and associated pupil responses are relat
Endogenous expression of L1 mRNA is the first step in an L1-initiated mutagenesis event. However, the contribution of individual cell types to patterns of organ-specific L1 mRNA expression remains poorly understood, especially at single-locus resolution. We introduce a method to quantify expression ...
Evaluating the effect of selection on thepvron4locus No statistically significant values were found forpvron4when using the Tajima, Fu and Li, Fay and Wu and Fu estimators (Table2). Likewise, the MK test did not reveal any deviations regarding neutrality (Table3), however, the dN− dSdi...
to associations explaining less than 1 %. These effect sizes are large relative to clinical traits, presumably because the effect on binding of transcription or splicing factors is direct. It is worth keeping in mind that the relevant expression may be in a tissue other than the one being prof...
Quantitative trait association analyses using LBC1936 samples were performed by linear regression of the trait residuals (adjusted for age and sex) on the number of minor alleles at each SNP, with empirical P-values estimated by permutation to avoid issues with the test statistic distribution caused...