This is increased by administration via inhalation, resulting in targeting of the drug directly to the site of action. However, all drugs deposited in the airways are eliminated via the systemic circulation, and have, therefore, the potential to cause some systemic side effects....
Estradiol (Systemic, Local) Dosage and AdministrationGeneralA progestin generally is added to estrogen therapy (HRT) in women with an intact uterus. Addition of a progestin for ≥10 days per cycle of estrogen administration or daily with estrogen reduces incidence of endometrial hyperplasia and ...
These results indicate that a TAP block can potentially cause systemic toxicity of a local anesthetic. The analgesic effect of the TAP block may partially... N Kato,Y Fujiwara,M Harato,... - 《Journal of Anesthesia》 被引量: 186发表: 2009年 Mitochondrial off targets of drug therapy The ...
aFor a drug with local action it is essential - in the design of new drug-formulations and for the understanding of the dynamics at the intraluminal and tissue-level - to have a firm basis of knowledge not only of systemic fate of drug but also of drug-kinetics which are characteristic ...
Uses for Acetylcysteine, Acetylcysteine Lysine(Local, Systemic)Antidote for Acetaminophen OverdosageTreatment of acetaminophen overdosage following acute ingestion or repeated supratherapeutic ingestion. IV acetylcysteine designated an orphan drug by FDA for this use. Optimal if given within 8 hours of ...
To overcome the side effects caused by systemic administration of doxorubicin, nanosized polymeric micelles were used in combination with dual frequency ultrasonic irradiation. These micelles release the drug due to acoustic cavitation, which is enhanced in dual frequency ultrasonic fields. To form the ...
Repeatable ultrasound-triggered nerve blocks were achieved in vivo, with the nerve-block duration depending on the extent and intensity of insonation. There was no detectable systemic toxicity and tissue reaction was benign in all groups. On-demand, personalized local anaesthesia could be beneficial ...
To determine the systemic effect of decreased serum IgA, CLP was performed in RankF/F;VilERT2Cre and NikF/F;VilERT2Cre mice. Interestingly, the induction of serum IL17 following CLP was significantly abrogated in RankF/F;VilERT2Cre and NikF/F;VilERT2Cre mice (Fig. 7g, h). Moreover, ...
Use of probiotic bacteria for prevention and therapy of allergic diseases: studies in mouse model of allergic sensitization. bacteria prevented the development of Parietaria major allergen-specific response, by down-regulating T helper cell 2 responses at the local and systemic ... Gabriella,Di,Felice...
A. The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis. Nat. Cell Biol. 16, 717–727 (2014). Article CAS PubMed PubMed Central Google Scholar Marusyk, A. et al. Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity. ...