Define local anesthetic. local anesthetic synonyms, local anesthetic pronunciation, local anesthetic translation, English dictionary definition of local anesthetic. n. An anesthetic drug that induces local anesthesia by inhibiting nerve excitation or con
Treatment of Idiopathic Granulomatous Mastitis: Local Steroid Administration vs. Systemic (Oral) SteroidTURKEYANTIBIOTICSDRUG efficacyADRENOCORTICAL hormonesINJECTIONSORAL drug administrationRETROSPECTIVE studiesMASTITISCOMPARATIVE studiesDISEASE relapseIdiopathic granulomatous mastitis is characterized by non-caseating ...
Paul…undercuts the liberal argument that spending on progressive policies can create systemic change. …Black residents…are worse off today by some measures than they were 20 and 30 years ago, even as the fortunes of their white counterparts held steady or improved, according to census data....
US5176917 * 1991年7月12日 1993年1月5日 Lts Lohmann Transdermal system exhibiting graduated drug release and its use for the local or systemic administration of active substancesUS5176917 * Jul 12, 1991 Jan 5, 1993 Lts Lohmann Transdermal system exhibiting graduated drug release and its use for...
Acetylcysteine drug interactions (more detail)Acetylcysteine, Acetylcysteine Lysine(Local, Systemic) PharmacokineticsAbsorptionBioavailabilityAbsorbed following oral administration, with peak plasma concentrations achieved within 1–2 hours.DistributionExtentCrosses the placenta....
However, systemic administration for peptide receptor radionuclide therapy still lacks the therapeutic index to completely treat solid tumors beyond palliation. We study intra-arterial delivery with tumor embolization of a small molecule as a means to deliver local intertumoral brachytherapy for curative ...
Figure 6. Effect of drug localization on widening the therapeutic index [132]. Widening the therapeutic index is an important challenge in immunotherapy [54], [133]. Local administration can increase the concentration in the desired tissue (hence enhance efficacy) while lowering the systemic concentr...
Taken together, the above observations identify the cAMP pathway as an attractive target for therapeutic intervention in melanoma growth, but its innumerable physiological functions prohibit systemic intervention in the pathway. In this work, we show that the nucleotide cyclase inhibitor MDL-12,330A20 ...
SYSTEMIC DELIVERY Two attributes of EVA which have made it well suited for delivering drug molecules systemically are (1) its high drug loading capability and (2) its straightforward mechanisms for fine tuning drug-release rates. Examples of such mechanisms include changing the vinyl...
4A). Frequency distribution analysis of WFA staining intensities in intact female CA1 PV-INs showed that systemic aromatase blockade increased the intensity of WFA staining surrounding female PV-INs (Fig. 4B). Intracerebral administration of the aromatase blocker through a guide cannula implanted in ...