[9] Muramatsu H, Lam K, Bajusz C, Laczkó D, Karikó K, Schreiner P, Martin A, Lutwyche P, Heyes J, Pardi N. Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine. Mol Ther. 2022 M...
A network analysisof COVID-19 mRNA vaccine patents Rosenblum et al.,Sci.Adv. 2020; 6 : eabc9450 The mRNA-LNP platform’s lipid nanoparticlecomponent used in preclinical vaccine studies is highly inflammatory A.K.Blakney, S.Ip, A.J.Geall, An Update ...
总之,作者首次应用SA-及Pchs于肿瘤疫苗;所制备的LNP-mRNA肿瘤疫苗兼具DCs靶向性和高效的内体逃逸;能够提高抗肿瘤效果,降低毒副作用。 感兴趣的朋友可以点击Simultaneous dendritic cells targeting and effective endosomal escape enhance sialic acid-modified mRNA vaccine efficacy and reduce side effects - ScienceDire...
Addressing the Cold Reality of mRNA Vaccine Stability. Journal of pharmaceutical sciences. 2021,110: 997–1001. 迈安纳(上海)仪器科技有限公司专注于解决RNA纳米药物递送行业痛点的整体解决方案本土提供商。公司不仅可提供从实验室到产业化的核酸(包括mRNA,siRNA,CRISPR/Cas9,SAMRNA,CircRNA等)-LNP全系列封装设备...
The mRNA-LNP vaccine has received much attention during the COVID-19 pandemic since it served as the basis of the most widely used SARS-CoV-2 vaccines in Western countries. Based on early clinical trial data, these vaccines were deemed safe and effective for all dem...
2022年8月15日，许巧兵教授在《Proceedings of the National Academy of Sciences》（PNAS）国际知名期刊上发表了题为“Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response”的研究论文。这篇论文向我们报道了一种基于脂质纳米颗粒的淋巴结靶向mRNA...
来自Tufts大学的Qiaobing Xu教授于2022年在PNAS发表了题为《Lipid nanoparticle-mediated lymph node–targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response.》的文章。他们在不使用靶头的前提下,通过筛选阳离子脂质,筛选到了一种拥有淋巴结(LN)靶向性的阳离子脂质及其配方,将其应用于肿瘤...
宾夕法尼亚大学与德国BioNTech学者共同在Molecular Therapy发表过一篇文章:Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine。 图3:Molecular Therapy研究文章 用SP Scientific VirTis Genesis 35L Pilot Lyophilizer冻干机(见图4),对脂质纳米颗粒为载体的修...
2023 年 5 月 8 号,Jean Haensler 等人在 Molecular Therapy 发表文章:The impact ofnucleosidebase modification in mRNA vaccine is influenced by the chemistry of its lipid nanoparticle delivery system,他们使用 3 种阳离子脂质:MC3,KC2,L319,制备 LNP,包封编码 H1N1 流感病毒血凝素蛋白(hemagglutinin)的...
2022年3月23号,AAHI合作者Corey Casper在BioRxiv上传文章:《A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability》。他们开发出一款编码新冠病毒Spike 抗原的自复制mRNA疫苗(samRNA),利用可冻干且耐温的纳米结构脂质载体NLC(Nanostructured Lipid Carrier)包封samRNA。NLC纳米颗粒...