综上,本研究阐明了lncRNA TRPM2-AS是胆囊癌血管生成中的关键促进分子,并证实IGF2BP2-TRPM2-AS/PABPC1-NUMB-NOTCH1是胆囊癌中一种新的促血管生成轴,这提示TRPM2-AS作为胆囊癌中新的且有前途的血管生成生物学标志物,为未来胆囊癌...
Downregulation of lncTRPM2-AS promoted apoptosis and inhibited proliferation and production of cytokines including IL-1尾, IL-4, IL-6, IL-10, TNF-伪, and TGF-尾. RNA-immunoprecipitation and mass spectrometry indicated that the protein TRPM2 interacted with both lncTRPM2-AS and the E3 ...
Long noncoding RNAs (lncRNAs) are emerging as important regulators of tumorigenesis and angiogenesis in EC. However, the underlying mechanisms of lncRNA TRPM2-AS in EC are still not clear. Methods: We screened the differently expressed lncRNAs that were highly associated with poor prognosis and ...
This study aimed to verify the proliferative and anti-apoptotic effect of lncRNA TRPM2-AS/miR-140-3p/PYCR1 axis on BC based on WGCNA. WGCNA was applied for determining hub genes using gene expression data gained from breast cancer and adjacent tissues which were downloaded from the Cancer ...
LncTRPM2-AS inhibits TRIM21-mediated TRPM2 ubiquitination and prevents autophagy-induced apoptosis of macrophages in asthmadoi:10.1038/s41419-021-04437-6Xiaoping LiWenwen WangYu ShaoJinping Zhang
In the current study, we investigated the association of TRPM2-AS and HNF1A-AS1 single nucleotide polymorphisms (SNPs) with MS risk in 300 Iranian patients and 300 healthy controls. Our results have shown that T allele of the rs933151 was statistically significant underrepresented in MS patients ...