首先,关键的功能获得和功能缺失实验表明MIAT在体外抑制细胞增殖和迁移;其次,在PTC细胞中EZH2被确定为miR-150-5p的直接下游靶标;此外,回补实验证明,EZH2表达的恢复部分消除了miR-150-5p的生物学效应;再者,MIAT的过表达与miR-150-5p表达呈负相关。综上所述,通过构建lncRNA-miRNA-mRNA网络,团队发现lncRNA MIAT可能通...
The initial identification of long non-coding RNA myocardial infarction associated transcript (MIAT) as a genetic risk factor of myocardial infarction has made this lncRNA (designated as lncR-MIAT here) a focus of intensive studies worldwide. Emerging evidence supports that lncR-MIAT is susceptible...
研究表明,长链非编码RNA(long non coding RNA,LncRNA)能够发挥微小RNA(microRNA,miRNA)海绵作用,竞争性结合miRNA的反应元件,进而对其靶基因进行负向调控[7]。LncRNA心肌梗死相关转录本(myocardial infarction associated tran,MIAT)参与了心肌梗死、动脉粥样硬化等多种疾病过程[8],如结合miR-150部分增强心肌肥厚,结合mi...
研究表明,长链非编码RNA(long non coding RNA,LncRNA)能够发挥微小RNA(microRNA,miRNA)海绵作用,竞争性结合miRNA的反应元件,进而对其靶基因进行负向调控[7]。LncRNA心肌梗死相关转录本(myocardial infarction associated tran,MIAT)参与了心肌梗死、动脉粥样硬化等多种疾病过程[8],如结合miR-150部分增强心肌肥厚,结合mi...
LncRNA-MIAT靶向miR-150-5p对病理性血管化角膜及VEGF、MMP-9的影响 欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁欁氉 氉 氉 氉 引文格式：赵凌军，杨潇远，王新茹，李季．...
综上所述,LncRNA-MIAT通过调控miR-205表达对脓毒症大鼠AKI发挥肾脏保护作用,其机制可能与下调miR-205表达、减轻炎症反应及减少肾脏组织中细胞凋亡有关。但本研究样本数量较少,导致结果推广性受到影响。未来还需进一步拓展样本数量,全面、准确分析Ln...
Expression of MIAT presented a dramatic increase, while microRNA (miR)-133a-3p presented a dramatic decrease in atrium tissues of rats with AF induction. In addition, we also found that MIAT was highly expressed and miR-133a-3p was significantly reduced in peripheral blood leukocyte of AF ...
Long non-coding RNA-myocardial infarction-associated transcript (lncRNA-MIAT) has been reported to play an important role in the development of multiple cancers. However, the biological roles of MIAT in liver fibrosis are still unknown. In this study, the expression of MIAT is up-regulated durin...
lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA Circ. Res., 116 (7) (2015), pp. 1143-1156 View in ScopusGoogle Scholar [48] Y. Chen, Y. He, H. Zhou The potential role of lncRNAs in diabetes and diabetic microvascular complications Endocr. J.,...
2009). Recent studies have identified the regulatory machineries of a number of lncRNAs, such as HOTAIR, HOTTIP and XIST. MIAT was first identified as lncRNA a decade ago, series of researches had investigated the epigenetics and pathological effects of MIAT. In the terms of MI, two clinical...