LLDAS和缓解可降低损伤累积和复发风险,同时该研究发现,对于持续LLDAS或缓解状态而言,3个月可作为这种保护效应的阈值,且持续LLDAS或缓解时间越长,保护作用越强。 参考文献: [1]Golder V, Kandane-Rathnayake R, Li N, et al. Association of sustained lupus ...
Recently, meeting a definition of a lupus low disease activity state (LLDAS), analogous to low disease activity in rheumatoid arthritis, was preliminarily validated as associated with protection from damage accrual. The LLDAS definition has not been previously evaluated for association with patient-...
ObjectivesIn a post-hoc analysis, we aimed to validate the Lupus Low Disease Activity State (LLDAS) definition as an endpoint in an systemic lupus erythematosus (SLE) Phase IIb randomised controlled trial (RCT) (MUSE [NCT01438489]) and then utilize LLDAS to discriminate between anifrolumab ...
Lupus Low Disease Activity State(LLDAS)was defined as SLEDAI ≦4 and prednisolone(PSL)≦7.5mg/day. Definitions of Remission in SLE(DORIS)included patients with clinical and complete remission, clinical remission on treatment(ROT), and complete ROT.Results All remissions(DORIS)had LLDAS, and 78.4...
系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种全身多系统受累,临床表现复杂多样的自身免疫病。近年来,随着激素、免疫抑制剂的合理应用以及一些新兴生物制剂的出现,我国SLE患者的预后已有了很大改善,但SLE疾病本身所带来的肾脏、中枢神经系统受累等并发症,也使得SLE...
LLDAS和缓解可降低损伤累积和复发风险,同时该研究发现,对于持续LLDAS或缓解状态而言,3个月可作为这种保护效应的阈值,且持续LLDAS或缓解时间越长,保护作用越强。 参考文献: [1]Golder V, Kandane-Rathnayake R, Li N, et al. Association of sustained lupus low disease activity state with improved outcomes ...
Definition and initial validation of a Lupus Low Disease Activity State (LLDAS). Ann Rheum Dis 2016;75:1615-21.Franklyn K, Lau CS, Navarra SV, Louthrenoo W, Lateef A, Hamijoyo L, et al. Definition and initial validation of a lupus low disease activity state (LLDAS). Ann Rheum Dis....
Background Lupus Low Disease Activity State (LLDAS) is a consensus-based definition of minimally acceptable disease activity in patients with Systemic lupus erythematosus (SLE). Objectives The aims of this study were to evaluate what proportion of patients with LN fulfils the definition of LLDAS ...
LLDAS was defined as a SLEDAI <=4 with no activity in major organ systems, with no new features of lupus disease activity compared to the previous assessment, prednisone daily dose<=7.5 mg/d and maintenance IS drugs. Antimalarials were allowed in all groups. Damage accrual was ascertained ...
7Utility of the lupus low disease activity state (LLDAS) definition in discriminating responders in the phase IIB muse trial of anifrolumab in systemic lupus erythematosusreact-text: 129 ... /react-text react-text: 130 /react-textdoi:10.1136/lupus-2017-000215.7E MorandA Berglind...