Definition and initial validation of a lupus low disease activity state (LLDAS). Ann Rheum Dis 2016;75(9):1615-21.Franklyn K, Lau CS, Navarra SV, et al. Definition and initial validation of a Lupus Low Disease Activity State (LLDAS). Ann Rheum Dis. 2016;75:1615-21....
Treating to low disease activity is routine in rheumatoid arthritis, but no comparable goal has been defined for systemic lupus erythematosus (SLE). We sought to define and validate a Lupus Low Disease Activity State (LLDAS). A consensus definition of LLDAS was generated using Delphi and nominal...
[4]van Vollenhoven RF, Bertsias G, Doria A, et al. 2021 DORIS definition of remission in SLE: final recommendations from an international task force. Lupus Sci Med 2021; 8: e000538. 医脉通是专业的在线医生平台,“感知世界医学脉搏,助力中国临...
To evaluate the construct validity of the Lupus Low Disease Activity State (LLDAS), a treatment target in systemic lupus erythematosus (SLE). Fifty SLE case summaries based on real patients were prepared and assessed independently for meeting the operational definition of LLDAS. Fifty international ...
Treatment targets in systemic lupus erythematosus (SLE) have been validated in unselected—in terms of severity—cohorts, which limits their generalisability. We assessed remission (Definition of Remission in SLE (DORIS)) and Lupus Low Disease Activity State (LLDAS) in a historical cohort of 348 ...
系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种全身多系统受累,临床表现复杂多样的自身免疫病。近年来,随着激素、免疫抑制剂的合理应用以及一些新兴生物制剂的出现,我国SLE患者的预后已有了很大改善,但SLE疾病本身所带来的肾脏、中枢神经系统受累等并发症,也使得SLE...
OP0001 The lupus low disease activity state (LLDAS) definition discriminates responders in a systemic lupus erythematosus (SLE) trial: post-hoc analysis of the phase iib muse trial of anifrolumabBackground A LLDAS definition has received preliminarily validation. Achieving low disease activity by ...
ObjectivesIn a post-hoc analysis, we aimed to validate the Lupus Low Disease Activity State (LLDAS) definition as an endpoint in an systemic lupus erythematosus (SLE) Phase IIb randomised controlled trial (RCT) (MUSE [NCT01438489]) and then utilize LLDAS to discriminate between anifrolumab ...
7Utility of the lupus low disease activity state (LLDAS) definition in discriminating responders in the phase IIB muse trial of anifrolumab in systemic lupus erythematosusreact-text: 129 ... /react-text react-text: 130 /react-textdoi:10.1136/lupus-2017-000215.7E MorandA Berglind...
To evaluate the construct validity of the Lupus Low Disease Activity State (LLDAS), a treatment target in systemic lupus erythematosus (SLE). Fifty SLE case summaries based on real patients were prepared and assessed independently for meeting the operational definition of LLDAS. Fifty international ...