Zheng RQ,Wang QH,Lu MD, et al.Liver fibrosis in chronic viral hepatitis:an ultrasonographic study. World Journal of Gastroenterology . 2003Rong-Qin-Zheng,Qing-Hui Wang,Ming-De Lu,et al.Liver fibrosis in chronic viral hepatitis :An ultrasonographic study.World Journal of Gastroenterology. 2003...
Finally, although the bootstrap method was undertaken for internal validation39, a more rigorous validation with an independent external cohort is still needed to confirm the role of the mFIB-4 index in predicting liver fibrosis in patients with chronic viral hepatitis. In conclusion, our study ...
Nizatidine reduces liver fibrosis and cancer development in two animal models for chronic liver disease and HCC by impairing hepatocyte HRH2/CREB5 signaling Next, we validated the therapeutic effect of nizatidine in a rat model of progressive fibrotic liver disease and HCC based on repeated low-dose...
Acute-on-chronic liver failure (ACLF) is characterized by the acute deterioration of liver function, with organ/system failure and a short- to medium-term mortality of 50–90%1. In China and other Asian countries, hepatitis B virus (HBV) infection remains the leading cause of ACLF, accountin...
慢加急性肝衰竭(acute-on-chronic liver failure,ACLF)是在慢性肝病基础上发生的急性失代偿并伴有器官衰竭的临床综合征,短期病死率高。患者基线特征及健康状况是决定是否进行肝移植的重要基础,贯穿全程的多学科管理对于进一步提高ACLF患者生存率具有重要意义。
Currently, the role of MSC-Exo in preventing and treating acute and chronic liver injury is a research highlight. At the same time, the therapeutic mechanism of MSC-Exo in liver fibrosis, liver cancer and other diseases is also in full swing. However, it should also be pointed out that ...
5-AzadC is able to suppress HSC transdifferentiation providing further evidence of the importance of the DNA methylome in fibrosis [54]. However, given the likely need to treat chronic liver disease patients with anti-fibrotics for their lifetime it is difficult at present to envisage therapeutic...
ROS play an important role in fibrogenesis throughout increasing platelet-derived growth factor. Most hepatocellular carcinomas occur in cirrhotic livers, and the common mechanism for hepatocarcinogenesis is chronic inflammation associated with severe oxidative stress; other risk factors are dietary aflatoxin...
Steatohepatitis is a chronic hepatic inflammation associated with increased risk of hepatocellular carcinoma progression. Here the authors show that intestinal dysbiosis in mice lacking the inflammasome sensor molecule NLRP6 aggravates steatohepatitis and accelerates liver cancer progression, a process that can...
Hedgehog (Hh) signalling regulates hepatic fibrogenesis. MicroRNAs (miRNAs) mediate various cellular processes; however, their role in liver fibrosis is unclear. Here we investigate regulation of miRNAs in chronically damaged fibrotic liver. MiRNA profil