Liver fibrosis results from chronic damage to the liver in conjunction with the progressive accumulation of fibrillar extracellular matrix proteins. Fibrosis progression in patients with chronic viral hepatitis is a dynamic process where hepatic stellate cells, the most important contributor cell type, ...
In recent years, efforts have been made to develop non-invasive predictive models that may correlate with stage of fibrosis. One of the first non-invasive predictive models for patients with chronic hepatitis C (CHC) was the Fibrotest, which includes 展开 关键词: Liver fibrosis Diagnosis ...
Liver fibrosis is a wound-healing process of the liver in response to repeated and chronic liver injury with distinct etiologies, such as infectious diseases (e.g., viral hepatitis), metabolic derangements (non-alcoholic steatohepatitis), exposure to toxins (e.g., alcohol liver diseases), or au...
Stage II: Fibrosis Chronic inflammation causes scar tissue to grow in the liver, which replaces healthy functional liver tissue and impairs the liver’s functionality. The symptoms are usually mild or absent; however, some people may develop fatigueor discomfort in the stomach. If the underlying ...
Serum prolidase activity may be an index of liver fibrosis in chronic viral hepatitis It has been shown that an increase in prolidase enzyme activity is correlated with increased rates of collagen turnover. In previous studies, it has been i... Y Nazlgul,M Aslan,A Taskin,... - 《East...
Finally, although the bootstrap method was undertaken for internal validation39, a more rigorous validation with an independent external cohort is still needed to confirm the role of the mFIB-4 index in predicting liver fibrosis in patients with chronic viral hepatitis. In conclusion, our study ...
Chronic hepatitis without proper treatment will gradually led to fibrosis or scarring of the liver, causing liver cirrhosis, which directly weaken the regeneration capacity of the liver tissue, and eventually develop a liver ...
Prediction of fibrosis progression in chronic viral hepatitis. Clin. Mol. Hepatol. 20, 228–236 (2014). Article PubMed PubMed Central Google Scholar Lockart, I. et al. HCC incidence after hepatitis C cure among patients with advanced fibrosis or cirrhosis: a meta-analysis. Hepatology 76, ...
Hepatic fibrosis in patients with chronic hepatitis C assessed by transient elastography: Implications for determining the efficacy of antiviral therapy Background: the efficacy of combination therapy with peginterferon plus ribavirin to eradicate viral infection in patients with chronic hepatitis C (CHC) ...
In the present study, the following individuals were excluded: (1) individuals (n = 19) with cirrhosis of any etiology or chronic liver disease due to excessive alcohol consumption (alcohol consumption > 30 g/day for men and > 20 g/day for women) or viral hepatitis based on...