Liver fibrosis results from chronic damage to the liver in conjunction with the progressive accumulation of fibrillar extracellular matrix proteins. Fibrosis progression in patients with chronic viral hepatitis is a dynamic process where hepatic stellate cells, the most important contributor cell type, ...
Liver fibrosis is a dynamic pathological process of many chronic inflammatory diseases caused by genetic-related liver disease, chronic viral hepatitis, alcoholic liver disease, cholestasis, nonalcoholic steatohepatitis (NASH), and various drug damage (Wynn and Ramalingam, 2012; Zhao et al., 2019)....
Chronic hepatitis without proper treatment will gradually led to fibrosis or scarring of the liver, causing liver cirrhosis, which directly weaken the regeneration capacity of the liver tissue, and eventually develop a liver ...
Prediction of fibrosis progression in chronic viral hepatitis. Clin. Mol. Hepatol. 20, 228–236 (2014). Article PubMed PubMed Central Google Scholar Lockart, I. et al. HCC incidence after hepatitis C cure among patients with advanced fibrosis or cirrhosis: a meta-analysis. Hepatology 76, ...
Chronic hepatitis leads to cirrhosis and liver cancer, which are the final stages of the liver disease process. Hepatitis B virus (HBV) infection is one of the most common causes of chronic viral hepatitis, especially in developing countries. It was reported that HBV infection alters the expressi...
Background Liver fibrosis is a condition of abnormal proliferation of connective tissue due to various types of chronic liver injury often caused by viral infection and chemicals. Hep- atitis B viral (HBV) infection is the major cause of liver fibrosis in China, whereas hepatitis C viral (HCV...
enhanced liver fibrosis (ELF) score;chronic hepatitis;liver biopsy;FIB-4 1. Introduction Chronic liver disease, such as chronic hepatitis C, chronic hepatitis B, and steatotic liver disease, progresses to hepatocellular carcinoma (HCC) and liver decompensation, with HCC being one of the leading ca...
Stage II: Fibrosis Chronic inflammation causes scar tissue to grow in the liver, which replaces healthy functional liver tissue and impairs the liver’s functionality. The symptoms are usually mild or absent; however, some people may develop fatigueor discomfort in the stomach. If the underlying ...
Fibrosis is a common outcome of most chronic inflammatory diseases, characterized by the accumulation of excessive extracellular matrix components. Individuals with progressive liver fibrosis develop cirrhosis, are at risk of developing liver cancer, and may succumb to liver failure. Although a number of...
andchronic viral hepatitis.Nonalcoholic fatty liver disease(NAFLD) andalcoholic liverdiseases are two very common types ofchronic liver diseases[3]. Althoughliver fibrosisis the early stage of chronic liver disease, if left untreated, it will turn into irreversible cirrhosis andhepatocellular carcinoma...