Acute liver failure (ALF) is an uncommon condition in which rapid deterioration of liver function results in coagulopathy and alteration in the mental status of a previously healthy individual. Acute liver failure often affects young people and carries a
Acute liver failure (ALF) is a deadly illness due to insufficient detoxification in liver induced by drugs, toxins, and other etiologies, and the effective treatment for ALF is very limited. Among the drug-induced ALF, acetaminophen (APAP) overdose is the most common cause. However, the molecu...
We previously have documented the beneficial hepatoprotection conferred by M2-like macrophages in acute-on-chronic liver failure (ACLF) in vitro and in vivo, namely, M2-like macrophages protect hepatocytes against apoptosis. Herein, we integrated necroptosis, S100A9, and necroinflammation into this ...
The level of hepatic apoptosis was determined using a TUNEL kit (Beyotime, Shanghai, China), according to the manufacturer's protocol. An optical microscope (Lecia, Wetzlar, Germany) was used to analyze and image the tissues at different magnifications. Western blot Total protein from the liver...
and abdominal discomfort followed by rising ALT/AST and international normalized ratio 2 months after beginning treatment with ulipristal acetate for symptomatic fibroids [74]. Over the following 3–4 weeks, the patient continued to decline and eventually developed subacute liver failure with a model ...
Normally, where are AST (SGOT) and ALT (SGPT) in the body? AST (SGOT) is normally found in a variety of tissues including the liver, heart, muscle, kidney, and brain. It is released into the blood (serum) when any one of these tissues is damaged. For example, the AST level in ...
Numerous pathological processes that affect liver function in patients with liver failure have been identified. Among them, hyperammonia is one of the most common phenomena.The purpose of this study was to determine whether hyperammonia could induced specific liver injury. Methods Hyperammonemic cells...
Liver fibrosis is associated with an increased risk of complications, such as cirrhosis, hepatic failure, hepatocellular carcinoma, and even death [1,2,3]. NAFLD is also closely related to multiple significant extrahepatic manifestations, including chronic kidney disease, cardiovascular disease (CVD), ...
Relationship of thyroid dysfunction with cardiovascular diseases: updated review on heart failure progression Hormones (Athens), 19 (2020), pp. 301-309 CrossrefView in ScopusGoogle Scholar [190] M.R. Pagadala, C.O. Zein, S. Dasarathy, et al. Prevalence of hypothyroidism in nonalcoholic fatt...
Regarding some surveys, Vit-D deficiency increases PTH and hyperparathyroidism52 and PTH affects the myocardium both directly and indirectly through G protein-coupled receptors, causing left ventricular hypertrophy and an increased risk of heart failure53. On the other hand, the transfer of iron to ...