Region-specific changes of LSECs in liver cirrhosis were revealed by scRNA-seq technology (Su et al. 2021). Based on previously reported LSECs landmark genes, three clusters of LSECs were mapped into zone 1, 2,
Up to 50–70% of patients with liver cirrhosis develop hepatic encephalopathy (HE), which is closely related to gut microbiota dysbiosis, with an unclear mechanism. Here, by constructing gut–brain modules to assess bacterial neurotoxins from metagenomic datasets, we found that phenylalanine decarboxyl...
The transformed HSC synthesize α-smooth muscle actin (α-SMA) and extracellular matrix proteins such as collagen type 1. Therefore, it is thought that HSC aredoi:10.1053/j.gastro.2009.07.017Caroline TaylorElsevier Inc.Gastroenterology
This is a simplified diagram of the sinusoidal microcirculation in liver cirrhosis. In cirrhosis, however, the relationship between the portal and central veins is not maintained because of fibrous septa and regenerative nodules, which disrupt the normal vascular architecture of portal venules, sinusoid...
To further elucidate the specific hepatic cell type implicated in COVID-19 pathophysiology, scRNA-seq analysis was conducted on five representative liver tissue types, including healthy, human foetal, cirrhotic, tumour, and precancerous, comprising over 300,000 single cells. In liver cirrhosis, a ...
(MAFLD) has become the most prevalent non-communicable liver pathology9. MAFLD ranges from presymptomatic hepatic steatosis (fatty liver) to non-alcoholic steatohepatitis, which is characterized by inflammation, hepatocellular injury and fibrosis, and may progress to liver failure, cirrhosis and ...
(NK) cells, natural killer T cells, and adaptive immune cells, such as T and B cells.Disruption of the hepatic immune system can cause autoimmune hepatitis, steatohepatitis, cirrhosis, and liver cancer [15]. Although the positional relationships between the nerves and immune cells in the liver...
(NK) cells, natural killer T cells, and adaptive immune cells, such as T and B cells.Disruption of the hepatic immune system can cause autoimmune hepatitis, steatohepatitis, cirrhosis, and liver cancer [15]. Although the positional relationships between the nerves and immune cells in the liver...
Other studies used plasma protein profiling to identify proteins associated with NAFLD and Cirrhosis12,13 or to generate a steatosis classifier together with genetic and clinical parameters14. However, there is a lack of studies that systematically asses the translation of the molecular changes in the...
2004). The penetrance of single ABCB11 variants in BRIC-2 is variable as shown in siblings with the ABCB11-mutation p.G374S: while the brother developed liver cirrhosis, the sister experienced self-limiting jaundice with pruritus (Stindt et al. 2013). Intrahepatic cholestasis of pregnancy ...