The transformed HSC synthesize α-smooth muscle actin (α-SMA) and extracellular matrix proteins such as collagen type 1. Therefore, it is thought that HSC aredoi:10.1053/j.gastro.2009.07.017Caroline TaylorElsevier Inc.Gastroenterology
Region-specific changes of LSECs in liver cirrhosis were revealed by scRNA-seq technology (Su et al. 2021). Based on previously reported LSECs landmark genes, three clusters of LSECs were mapped into zone 1, 2, and 3 respectively. In comparison with the control group, genes associated ...
Ascites formation in patients with cirrhosis of the liver is dependent on local factors that preferentially localize any fluid retention to the peritoneal ... FJ Dudley - 《Gastroenterology Clinics of North America》 被引量: 64发表: 1992年 Hyponatremia in cirrhosis:Pathophysiology and management Hypona...
Given the high sensitivity of ultrasound diagnosis of cirrhosis, CT or MRI is not typically required for diagnosis. However, [12] did show that early stages of liver parenchymal abnormalities and morphological changes in the liver on MRI and CT were predictive of cirrhosis by multivariate analysis ...
Up to 50–70% of patients with liver cirrhosis develop hepatic encephalopathy (HE), which is closely related to gut microbiota dysbiosis, with an unclear mechanism. Here, by constructing gut–brain modules to assess bacterial neurotoxins from metagenomic datasets, we found that phenylalanine decarboxyl...
This is a simplified diagram of the sinusoidal microcirculation in liver cirrhosis. In cirrhosis, however, the relationship between the portal and central veins is not maintained because of fibrous septa and regenerative nodules, which disrupt the normal vascular architecture of portal venules, sinusoid...
(NK) cells, natural killer T cells, and adaptive immune cells, such as T and B cells.Disruption of the hepatic immune system can cause autoimmune hepatitis, steatohepatitis, cirrhosis, and liver cancer [15]. Although the positional relationships between the nerves and immune cells in the liver...
(NK) cells, natural killer T cells, and adaptive immune cells, such as T and B cells.Disruption of the hepatic immune system can cause autoimmune hepatitis, steatohepatitis, cirrhosis, and liver cancer [15]. Although the positional relationships between the nerves and immune cells in the liver...
(MAFLD) has become the most prevalent non-communicable liver pathology9. MAFLD ranges from presymptomatic hepatic steatosis (fatty liver) to non-alcoholic steatohepatitis, which is characterized by inflammation, hepatocellular injury and fibrosis, and may progress to liver failure, cirrhosis and ...
HBV is responsible for the most common form of chronic liver infection which may lead to liver fibrosis, cirrhosis, and hepatocellular carcinoma [34]. The inability to reproduce the complexity of the liver environment using conventional in vitro models – that usually include only primary human ...