Results Development of a liver cell-based system recapitulating the clinical PLS in cell culture To establish a liver cell-based system modeling the clinical PLS, we used the hepatoma-derived Huh7.5.1 cell line differentiated to acquire a hepatocyte-like phenotype (Huh7.5.1dif)10, as shown by...
The participants of the study (n = 28) were evaluated by transient hepatic elastography (FibroScan®; Echosens, Paris, France) and/or liver biopsy distributed into two groups according to the stage of liver fibrosis. The groups were classified according to the METAVIR score [6]: Group 1—...
Recommendations for Diagnosis, Referral for Liver Biopsy, and Treatment of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis. Mayo Clin. Proc. 2015, 90, 1233–1246. [Google Scholar] [CrossRef] [PubMed] Cao, Y.; Fang, X.; Sun, M.; Zhang, Y.; Shan, M.; Lan, X.; ...
However, a histopathological evaluation of biopsy specimens remains the gold standard for diagnosing NAFLD/NASH [46]. Long-term treatment with TNF-𝛼 𝑎𝑛𝑑 𝐼𝐹𝑁−𝛾α and IFN−γ induces the formation of MDB-like aggresomes and FAT10/Ubd expression [47], suggesting that ...