This finding was likely due to highly heterogeneous study populations due to etiology of liver disease, different post-LT time points for the assessment of liver fibrosis, study design and sample size and variable interval range between liver biopsy and the non-invasive assessment of liver fibrosis....
BRIDGE was offered to adult patients followed in the UCSF hepatology clinic with a diagnosis of MASLD by non-invasive testing or biopsy, at any stage of liver fibrosis. Patients with clinically significant portal hypertension were excluded from the BRIDGE cohorts, as their educational needs significan...
To establish a liver cell-based system modeling the clinical PLS, we used the hepatoma-derived Huh7.5.1 cell line differentiated to acquire a hepatocyte-like phenotype (Huh7.5.1dif)10, as shown by global transcriptome profile by 10 days of culture with dimethyl sulfoxide (DMSO; Supplementary Fi...
For hepatitis B, the FIB-4 index is included in AASLD guidance as an alternative to biopsy for assessing disease severity; this assessment helps guide treatment decisions for patients with chronic HBV infection, such as eligibility for antiviral therapy and therapy duration.3 For hepa...
Recommendations for diagnosis, referral for liver biopsy, and treatment of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Mayo Clin. Proc. 90, 1233–1246 (2015). Article PubMed Google Scholar Masarone, M., Federico, A., Abenavoli, L., Loguercio, C. & Persico, M. ...
[78]. Surprisingly, increased concentrations of IL-8, a consequence of hepatic gene expression, were found in 97 patients with biopsy-proven NAFLD, lending credence to such chemokines as ideal surrogate serum biomarkers for the severity of hepatic fibrosis [79]. Another attractive cytokine involved...
Each NAFLD patient underwent a liver biopsy and met the diagnostic criteria for NAFLD. The study was approved by the Ethics Committee of Xinhua Hospital affiliated to Shanghai Jiaotong University. The purpose and procedure of the study were explained to the participants before the samples were ...
no liver biopsy, measuring gamma-glutamyl transferase (GGT), hemoglobin A1c (HbA1c), body composition, and bioavailability and serum levels GC or its components, and determining the durability of the intervention in the long run, and 24-h food recall which is not appropriate for determining the...
While the definitive diagnosis of NAFLD is based on histologic examination of liver biopsy inherent risks associated with the procedure limits its widespread use as a screening test (http://www.medscape.com/viewarticle/497001_5). Therefore, ultrasound and other imaging modalities have been ...
enzymes, including ALT 6479 IU/L and AST 4254 IU/L on day 2 of admission [81]. Interestingly, this patient had a Tbili of 3.12 mg/dL on the day of admission, which continued to uptrend to a peak of 11.81 mg/dL on day 23. Liver biopsy was performed on day 23 of admission and ...