The protein-protein interaction network was built using LDL-receptor proteins and the top 50 tumor-associated genes. Low-density lipoprotein-related receptors 5/6 (LRP5/6) in endometrial cancer tissues were correlated with oncogenes, cell cycle-related genes, and immunological checkpoints using ...
doi:10.1007/3-540-29623-9_7692Low density lipoprotein receptor related proteins 5 and 6 (LRP5/6) define large Type I transmembrane receptors which serve as co-receptors for Wnt. Mutation of the DrosophilaLRP5/6 homologue, Arrow,...Springer Berlin Heidelberg...
Moreover, mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins (Pinson et al., 2000). Despite the evidence that the Fz and LRP proteins are receptors for the Wnt proteins, it is not known how these receptor proteins ...
Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity ... Polymorphisms in the LRP5 gene have been associated with bone mineral density (BMD) in men and/or women. However, the functional basis ...
[152,153]. Lipoprotein receptor-related proteins LRP1 and LRP2 are often used for targeted delivery across the BBB [154]. Low-density lipoprotein receptor is a glycoprotein that has characteristics of different families of receptors. The ligand-binding site is cysteine-rich; it has a region ...
Prolow-density lipoprotein receptor-related protein 1 ELISA Kit的详细说明书 检测范围:0.156-10 ng/mL 使用:本试剂仅供科研使用 保存:2-8℃ 有效期:6个月 检测方法:ELISA 产品性状:96T/48T,盒装液体 贮藏条件:2-8°C ELISA试剂盒实验原理: ELISA是以免疫学反应为基础,将抗原、牽9体的特异性反应与酶对底...
Mutations in low-density lipoprotein receptor-related protein 5 (Lrp5) impair retinal angiogenesis in patients with familial exudative vitreoretinopathy (FEVR), a rare type of blinding vascular eye disease. The defective retinal vasculature phenotype in human FEVR patients is recapitulated in Lrp5 knock...
Lipoproteins differ in their relative concentrations of protein to lipid and in their constituent lipids and proteins (Table 37.2). The densities of lipoproteins are inversely related to their size. The lipoproteins can be classified on the basis of their size, density or protein composition. The ...
Notably, sHDL strongly dampens the Toll-Like Receptor signaling pathway facing LPS stimulation, mainly by downregulating at least 3-fold the pro-inflammatory genes, such as Il1b, Il1a, Il6, Ptgs2, and Tnf. In vivo, the lipoprotein nanoparticle applied after NaOCl reduced bone resorption ...
HDL-C can also be taken up directly by hepatocytes via the scavenger receptor class BI (SR-BI), a cell surface receptor that mediates the selective transfer of lipids to cells. HDL particles undergo extensive remodeling within the plasma compartment by a variety of lipid transfer proteins and ...